Publications
1. Park J, Seo T, Hwang S, Lee D, Gwack Y, Choe J. 2000. The K-bZIP protein from Kaposi's sarcoma-associated herpesvirus interacts with p53 and represses its transcriptional activity. J Virol 74:11977-82.
2. Lim C, Gwack Y, Hwang S, Kim S, Choe J. 2001. The transcriptional activity of cAMP response element-binding protein-binding protein is modulated by the latency associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus. J Biol Chem 276:31016-22.
3. Gwack Y, Byun H, Hwang S, Lim C, Choe J. 2001. CREB-binding protein and histone deacetylase regulate the transcriptional activity of Kaposi's sarcoma-associated herpesvirus open reading frame 50. J Virol 75:1909-17.
4. Gwack Y, Hwang S, Byun H, Lim C, Kim JW, Choi EJ, Choe J. 2001. Kaposi's sarcoma-associated herpesvirus open reading frame 50 represses p53-induced transcriptional activity and apoptosis. J Virol 75:6245-8.
5. Hwang S, Gwack Y, Byun H, Lim C, Choe J. 2001. The Kaposi's sarcoma-associated herpesvirus K8 protein interacts with CREB-binding protein (CBP) and represses CBP-mediated transcription. J Virol 75:9509-16.
6. Byun H, Gwack Y, Hwang S, Choe J. 2002. Kaposi's sarcoma-associated herpesvirus open reading frame (ORF) 50 transactivates K8 and ORF57 promoters via heterogeneous response elements. Mol Cells 14:185-91.
7. Gwack Y, Hwang S, Lim C, Won YS, Lee CH, Choe J. 2002. Kaposi's Sarcoma-associated herpesvirus open reading frame 50 stimulates the transcriptional activity of STAT3. J Biol Chem 277:6438-42.
8. Hwang S, Lee D, Gwack Y, Min H, Choe J. 2003. Kaposi's sarcoma-associated herpesvirus K8 protein interacts with hSNF5. J Gen Virol 84:665-76.
9. Song MJ, Hwang S, Wong W, Round J, Martinez-Guzman D, Turpaz Y, Liang J, Wong B, Johnson RC, Carey M, Sun R. 2004. The DNA architectural protein HMGB1 facilitates RTA-mediated viral gene expression in gamma2 herpesviruses. J Virol 78:12940-50.
10. Rickabaugh TM, Brown HJ, Wu TT, Song MJ, Hwang S, Deng H, Mitsouras K, Sun R. 2005. Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus 8 RTA Reactivates Murine Gammaherpesvirus 68 from Latency. J Virol 79:3217-22.
11. Song MJ*, Hwang S*, Wong W, Wu TT, Lee S, Liao H, Sun R. 2005. Identification of Viral Genes Essential for Replication of Murine Gammaherpesvirus 68 Using Signature-Tagged Mutagenesis. Proc Nat Acad Sci 102:3805-10 (*equal contribution)
12. Xie MW, Jin F*, Hwang H*, Hwang S*, Anand V, Duncan MC, Huang, J. 2005. Insights into TOR function and rapamycin response: Chemical genomic profiling by using a high-density cell array method. Proc Nat Acad Sci 102:7215-20 (*equal contribution)
13. Tarakanova V, Leung-Pineda V*, Hwang S*, Yang C, Matatall K, Basson M, Sun R, Piwnica-Worms H, Sleckman BP, Virgin HW. 2007. Herpesvirus Kinase Actively Initiates a DNA Damage Response by Inducting Phosphorylation of H2AX to Foster Viral Replication. Cell Host & Microbe 1:275-86. (* equal contribution)
14. Lee S, Cho H, Park J, Kim Y, Hwang, S, Sun R, Song MJ. 2007. The ORF49 protein of murine gammaherpesvirus 68 cooperates with RTA in the regulation of virus replication. J Virol 81:9870-7.
15. Sanchez DJ, Miranda D Jr, Arumugaswami V, Hwang S, Singer AE, Senaati A, Shahangian A, Song MJ, Sun R, Cheng G. 2008. A Repetitive Region of Gamma-herpesvirus Genomic DNA Is a Ligand for Induction of Type I Interferon. J Virol 82:2208-17.
16. Hwang S, Wu TT, Tong LM, Kim KS, Martinez-Guzman D, Colantonio AD, Uittenbogaart CH, Sun R. 2008. Persistent Gamma-Herpesvirus Replication and Its Dynamic Interaction with Host In Vivo. J Virol 82:12498-509.
17. Cheng LS, Hwang S, Huang TH, Sheu TC, Sun R, Morrison SL, Cheng G, Shahangian A. 2008. Antibody-fused interferons as an effective approach to enhance target specificity and antiviral efficacy of type I interferons. Cell Res 18:1-3.
18. Arumugaswami V, Sitapara R, Hwang S, Song MJ, Ho TN, Su NQ, Sue EY, Kanagavel V, Xing F, Zhang X, Zhao M, Deng H, Wu TT, Kanagavel S, Zhang L, Dandekar S, Papp J, Sun R. 2009. High-resolution Functional Profiling of a Gamma-herpesvirus RTA Locus in the Context of the Viral Genome. J Virol 83:1811-22.
19. Miyahira AK, Shahangian A, Hwang S, Sun R, Cheng G. 2009. TANK-Binding Kinase-1 Plays an Important Role during In Vitro and In Vivo Type I IFN Responses to DNA Virus Infections. J Immunol 182:2248-57.
20. Hwang S, Kim KS, Flano E, Wu TT, Tong LM, Park AN, Song MJ, Sanchez DJ, O’Connell RM, Cheng G, Sun R. 2009. Conserved Herpesviral Kinase Promotes Viral Persistence by Inhibiting the IRF-3-Mediated Type I Interferon Response. Cell Host & Microbe 5:166-178.
21. Liao HI, Olson CA, Hwang S, Deng H, Wong E, Baric RS, Roberts RW, Sun R. 2009. mRNA display design of fibronectin-based intrabodies that detect and inhibit sars-cov N protein. J Biol Chem 284:17512-20.
22. E X*, Hwang S*, Oh S*, Lee JS, Jeong JH, Gwack Y, Kowalik TF, Sun R, Jung JU, Liang C. 2009. Viral Bcl-2-mediated evasion of autophagy aids chronic infection of gammaherpesvirus 68. PLoS Pathog 5(10): e1000609. (* equal contribution)
23. Oh S, E X, Hwang S, Liang C. 2010. Autophagy evasion in herpesviral latency. Autophagy 6:151-2.
24. Jia Q, Freeman ML, Yager EJ, McHardy I, Tong L, Martinez-Guzman D, Rickabaugh T, Hwang S, Blackman MA, Sun R, Wu TT. 2010. Induction of protective immunity against murine gammaherpesvirus-68 infection in the absence of viral latency. J Virol 84:2453-2465.
25. Leang RS, Wu TT, Hwang S, Liang LT, Tong L, Truong JT, Sun R. 2011. The Anti-interferon Activity of Conserved Viral dUTPase ORF54 is Essential for an Effective MHV-68 Infection. PLoS Pathog 7(10):e1002292.
26. Kang HR, Cho HJ, Kim S, Song IH, Lee TS, Hwang S, Sun R, Song MJ. 2012. Persistent infection of a gammaherpesvirus in the central nervous system. Virology 423(1):23-9.
27. Starr T, Child R, Wehrly TD, Hansen B, Hwang S, López-Otin C, Virgin HW, Celli J. 2012. Selective Subversion of Autophagy Complexes Facilitates Completion of the Brucella Intracellular Cycle. Cell Host & Microbe 11:33-45.
28. Razani B, Feng C, Coleman T, Emanuel R, Wen H, Hwang S, Ting JP, Virgin HW, Kastan MB, Semenkovich CF. 2012. Autophagy Links Inflammasomes to Atherosclerotic Progression. Cell Metabolism 15:534-44.
29. Hwang S*, Maloney NS*, Bruinsma MW, Goel G, Duan E, Zhang L, Shrestha B, Diamond MS, Dani A, Sosnovtsev SV, Green KY, Lopez-Otin C, Xavier RJ, Thackray LB+, and Virgin HW+. 2012. Non-degradative Role of Atg5-Atg12/Atg16L1 Autophagy Protein Complex in Antiviral Activity of Interferon gamma. Cell Host & Microbe 11:397-409. (* equal contribution; + co-corresponding)
30. Chong A, Wehrly TD, Child R, Hansen B, Hwang S, Virgin HW, Celli J. 2012. Cytosolic clearance of replication-deficient mutants reveals Francisella tularensis interactions with the autophagic pathway. Autophagy 8:1342-56.
31. Klionsky DJ, …, Hwang S, et al. 2012. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 8:445-544.
32. Maloney NS, Thackray LB, Goel G, Hwang S, Duan E, Vachharajani P, Xavier R, Virgin HW. 2012. Essential Cell-Autonomous Role for Interferon (IFN) Regulatory Factor 1 in IFN-γ-Mediated Inhibition of Norovirus Replication in Macrophages. J Virol 86:12655-64.
33. Case ED, Chong A, Wehrly TD, Hansen B, Child R, Hwang S, Virgin HW, Celli J. 2013. The Francisella O-antigen mediates survival in the macrophage cytosol via autophagy avoidance. Cell Microbiol. 16:862-77.
34. Hwang S, Alhatlani B, Arias A, Caddy SL, Christodoulou C, Cunha J, Emmott E, Gonzalez-Hernandez M, Kolawole A, Lu J, Rippinger C, Sorgeloos F, Thorne L, Vashist S, Goodfellow I, Wobus CE. 2014. The Murine Norovirus: Propagation, Quantification and Genetic Manipulation. Curr Protoc Microbiol. 33:15K.2.1-15K.2.61.
35. Qiang L, Zhao B, Ming M, Wang N, He T, Hwang S, Thorburn A, He Y. 2014. Regulation of cell proliferation and migration by p62 through stabilization of Twist1. Proc Nat Acad Sci 111:9241-6.
36. Choi J, Park S, Biering SB, Selleck E, Liu CY, Zhang X, Fujita N, Saitoh T, Akira S, Yoshimori T, Sibley LD, Hwang S*, Virgin HW*. 2014. The Parasitophorous Vacuole Membrane of Toxoplasma gondii is Targeted for Disruption by Ubiquitin-like Conjugation Systems of Autophagy. Immunity 40:924-35. (* co-corresponding)
37. Kratz M, Coats BR, Hisert KB, Hagman D, Mutskov V, Peris E, Schoenfelt KQ, Kuzma JN, Larson I, Billing PS, Landerholm RW, Crouthamel M, Gozal D, Hwang S, Singh PK, Becker L. 2014. Metabolic Dysfunction Drives a Mechanistically Distinct Proinflammatory Phenotype in Adipose Tissue Macrophages. Cell Metab. 20(4):614-25.
38. Vashist S, Urena L, Gonzalez-Hernandez MB, Choi J, de Rougemont A, Rocha-Pereira J, Neyts J, Hwang S, Wobus CE, Goodfellow I. 2015. The molecular chaperone Hsp90 is a therapeutic target for noroviruses. J Virol 89(12):6352-63.
39. Klionsky DJ, …, Hwang S, et al. 2016. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12:1-222.
40. Redmann V, Lamb CA, Hwang S, Orchard RC, Kim S, Razi M, Milam A, Park S, Yokoyama CC, Kambal A, Kreamalmeyer D, Bosch MK, Xiao M, Green K, Kim J, Pruett-Miller SM, Ornitz DM, Allen PM, Beatty WL, Schmidt RE, DiAntonio A, Tooze SA, Virgin HW. 2016. Clec16a is Critical for Autolysosome Function and Purkinje Cell Survival. Scientific Reports 6, Article number: 23326.
41. Park S*, Choi J*, Biering SB, Dominici E, Williams LE, Hwang S. 2016. Targeting by AutophaGy proteins (TAG): Targeting of interferon-gamma induced GTPases to membranes by the LC3 conjugation system of autophagy. Autophagy 12:1-15 (* equal contribution)
42. Choi J, Biering SB, Hwang S. 2016. Quo vadis? Interferon-inducible GTPases go to their target membranes via the LC3-conjugation system of autophagy. Small GTPases 8:199-207. http://dx.doi.org/10.1080/21541248.2016.1213090
43. Biering SB*, Choi J*, Halstrom RA, Brown HM, Beatty WL, Lee S, McCune BT, Dominici E, Williams LE, Orchard RC, Wilen CB, Yamamoto M, Coers J, Taylor GA, Hwang S. 2017. Viral replication complexes are targeted by LC3-guided interferon-inducible GTPases. Cell Host & Microbe 22(1):74-85.e7 (* equal contribution)
44. Biering SB, Choi J, Brown HM, Hwang S. 2017. LC3s hire membrane breakers to attack viral shelters. Autophagy 13:2010-2012.
45. Matsuzawa-Ishimoto Y*, Hwang S*, and Cadwell K*. 2017. Autophagy and Inflammation. Annual Review of Immunology (* co-corresponding) 36:73-101.
46. Yokoyama CC, Baldridge MT, Leung DW, Zhao G, Desai C, Liu T, Diaz-Ochoa VE, Huynh JP, Kimmey JM, Sennott EL, Hole CR, Idol RA, Park S, Storek KM, Wang C, Hwang S, Milam AV, Chen E, Kerrinnes T, Starnbach MN, Handley SA, Mysorekar IU, Allen PM, Monack DM, Dinauer MC, Doering TL, Tsolis RM, Dworkin JE, Stallings CL, Amarasinghe GK, Micchelli CA, Virgin HW. 2018. LysMD3 is a type II membrane protein without an in vivo role in the response to a range of pathogens. J Biol Chem 293(16):6022-6038.
47. Brown HM, Biering SB, Zhu A, Choi J, Hwang S. 2018. Demarcation of Viral Shelters Results in Destruction by Membranolytic GTPases: Antiviral Function of Autophagy Proteins and Interferon-Inducible GTPases. BioEssays 40(6):e1700231.
48. Coers, J, Brown HM, Hwang S, Tayler GA. 2018. Partners in anti-crime: how interferon-inducible GTPases and autophagy proteins team up in cell-intrinsic host defense. Current Opinion in Immunology 54:93-101.
49. Lee JH, Park BS, Han KR, Biering SB, Kim SJ, Choi J, Seok JH, Alam I, Chung MS, Kim HM, Hwang S*, Kim KH*. 2018. Insight into the interaction between RNA polymerase and VPg for murine norovirus replication. Frontiers in Microbiology 9:1466. (* co-corresponding)
50. Han KR, Lee JH, Kotiguda GG, Jung KH, Chung MS, Kang S, Hwang S, Kim KH. 2018. Nucleotide triphosphatase and RNA chaperone activities of murine norovirus NS3. J Gen Virol 99(11):1482-1493.
51. Bechelli J, Vergara L, Smalley C, Buzhdygan T, Bender S, Zhang W, Liu Y, Popov V, Wang J, Garg N, Hwang S, Walker D, Fang R. 2018. Atg5 Supports R. australis Infection in Macrophages in vitro and in vivo. Infect Immun 87(1). pii: e00651-18.
52. Kang S, Brown HM, Hwang S. 2018. Direct antiviral mechanisms of interferon-gamma. Immune Network 18(5):e33.
53. Bouziat R+, Biering SB+, Kouame E, Sangani KA, Kang S, Ernest JD, Varma M, Brown JJ, Urbanek K, Dermody TS, Ng A, Hinterleitner R, Hwang S*, Jabri B*. 2018. Murine Norovirus Infection Induces TH1 Inflammatory Responses to Dietary Antigens. Cell Host & Microbe (+ equal contribution; * co-corresponding) 24(5):677-688.e5.
54. Furlong K, Hwang S. 2019. Autophagy and Noroviruses. Viruses 11(3). pii: E244.
55. Yang S, Wei J, Cui YH, Park G, Shah P, Deng Y, Aplin AE, Lu Z, Hwang S, He C, He YY. 2019. m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade. Nat Commun 10(1):2782.
56. McPhillie MJ, Zhou Y, Hickman MR, Gordon JA, Weber CR, Li Q, Lee PJ, Amporndanai K, Johnson RM, Darby H, Woods S, Li ZH, Priestley RS, Ristroph KD, Biering SB, El Bissati K, Hwang S, Hakim FE, Dovgin SM, Lykins JD, Roberts L, Hargrave K, Cong H, Sinai AP, Muench SP, Dubey JP, Prud'homme RK, Lorenzi HA, Biagini GA, Moreno SN, Roberts CW, Antonyuk SV, Fishwick CWG, McLeod R.2020. Potent Tetrahydroquinolone Eliminates Apicomplexan Parasites. Front Cell Infect Microbiol. Jun 9;10:203. doi: 10.3389/fcimb.2020.00203. eCollection 2020.
57. Furlong K, Biering SB, Choi J, Wilen CB, Orchard RC, Wobus CE, Nelson CA, Fremont DH, Baldridge MT, Randall G, Hwang S. 2020. CD300LF Polymorphisms of Inbred Mouse Strains Confer Resistance to Murine Norovirus Infection in a Cell Type-Dependent Manner. J Virol. Aug 17;94(17):e00837-20. doi: 10.1128/JVI.00837-20. Print 2020 Aug 17.
58. Finethy R, Dockterman J, Kutsch M, Orench-Rivera N, Wallace GD, Piro AS, Luoma S, Haldar AK, Hwang S, Martinez J, Kuehn MJ, Taylor GA, Coers J. 2020. Dynamin-related Irgm proteins modulate LPS-induced caspase-11 activation and septic shock. EMBO Rep. Nov 5;21(11):e50830. doi: 10.15252/embr.202050830. Epub 2020 Oct 30.
59. Klionsky DJ, …, Hwang S, et al. 2021. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy Feb 8:1-382. doi: 10.1080/15548627.2020.1797280.
60. Cathcart AL, Havenar-Daughton C, Lempp FA, Ma D, Schmid M, Agostini ML, Guarino B, Di iulio J, Rosen L, Tucker H, Dillen J, Subramanian S, Sloan B, Bianchi S, Wojcechowskyj J, Zhou J, Kaiser H, Chase A, Montiel-Ruiz M, Czudnochowski N, Cameroni E, Ledoux S, Colas C, Soriaga L, Telenti A, Hwang S, Snell G, Virgin HW, Corti D, Hebner CM. 2021. The dual function monoclonal antibodies VIR-7831 and VIR-7832 demonstrate potent in vitro and in vivo activity against SARS-CoV-2. bioRxiv doi: https://doi.org/10.1101/2021.03.09.434607
61. Anglero-Rodriguez Y, Lempp FA, McIninch J, Schlegel MK, Brown CR, Foster DJ, Castoreno AB, Nguyen T, Subramanian M, Montiel-Ruiz M, Kaiser H, Sahakyan A, Spreafico R, Morskaya SS, Barry JD, Berman D, Lefebvre S, Kasper A, Racie T, Weddle D, Mobley M, Rogers A, Dybowski J, Chong S, Nair J, Simon A, Sloan K, Hwang S, Virgin HW, Fitzgerald K, Maier MA, Hinkle G, Hebner C, Akinc A, Jadhav V. 2022. Robust and durable prophylactic protection conferred by RNA interference in preclinical models of SARS-CoV-2. biorxiv doi: https://doi.org/10.1101/2022.03.20.485044
62. Kurhade C, Kang S, Biering SB, Hwang S*, Randall G. 2023. CAPRIN1 is required for control of viral replication complexes by interferon gamma. mBio (*co-corresponding) DOI: https://doi.org/10.1128/mbio.00172-23
63. McAllaster MR, Bhushan J, Balce DR, Orvedahl A, Park A, Hwang S, Sullender ME, Sibley LD, Virgin HW. 2023. Autophagy gene-dependent intracellular immunity triggered by interferon-γ. mBio DOI: https://doi.org/10.1128/mbio.02332-23
64. Choi J, Park G, Lee SS, Dominici E, Becker L, Macleod KF, Kron SJ, Hwang S. 2024. Context-dependent roles for autophagy in myeloid cells in tumor progression. biorxiv doi: https://www.biorxiv.org/content/10.1101/2024.07.12.603292v1
65. Pero JE, Mueller EA, Adams A, Adolph AS, Bagchi P, Balce D, Bantscheff M, Barauskas O, Bartha I, Bohan D, Cai H, Carabajal E, Cassidy J, Cato M, Chaudhary KW, Chen D, Chen Y, Colas C, Darwech I, Eberl HC, Fernandez B, Gordon E, Grosse J, Hansen J, Hetzler BE, Hwang S, Jeyasingh S, Kowalski B, Lehmann S, Lo G, McAllaster M, McHugh C, Momont C, Newby Z, Nigro MR, Oladunni F, Pannirselvam M, Park A, Pearson N, Peat AJ, Plastridge B, Ranjan R, Safabakhsh P, Shapiro N, Soriaga L, Stokes NR, Sweeny D, Talecki L, Telenti A, Terrell A, Tse WC, Wang L, Wang S, Wedel L, Werner T, Wilk DD, Yim SS, Zhou J. 2024. Discovery of potent STT3A/B inhibitors and the assessment of their multi-pathogen antiviral potential and safety. J Med Chem 22;67(16):14586-14608. doi: 10.1021/acs.jmedchem.4c01402.
66. Soriaga L, Balce D, Bartha I, Park A, Wong E, McAllaster M, Mueller EA, Barauskas O, Carabajal E, Kowalski B, Lee S, Lo G, Mahoney TF, Metruccio M, Sahakyan A, Somasundaram L, Steinfeld T, Wang L, Wedel L, Yim SS, Yin L, Zhou J, Newby A, Tse W, Grosse J, Virgin HW, Hwang S*, Telenti A*. 2024. Shared host genetic landscape of respiratory viral infection. (*co-corresponding) (submitted)