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Lin28 promotes transformation and is associated with advanced human malignancies

Publication: Journal Article

Viswanathan, S. R., J. T. Powers, W. Einhorn, Y. Hoshida, T. L. Ng, S. Toffanin, M. O’Sullivan, et al. 2009. “Lin28 Promotes Transformation and Is Associated With Advanced Human Malignancies”. Nat Genet 41: 843-8.

Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling

Publication: Journal Article

Wawer, M. J., K. Li, S. M. Gustafsdottir, V. Ljosa, N. E. Bodycombe, M. A. Marton, K. L. Sokolnicki, et al. 2014. “Toward Performance-Diverse Small-Molecule Libraries for Cell-Based Phenotypic Screening Using Multiplexed High-Dimensional Profiling”. Proc Natl Acad Sci U S A 111: 10911-6.

Three-dimensional Chromatin Landscapes in T cell Acute Lymphoblastic Leukemia

Publication: Journal Article

Kloetgen, Andreas, Palaniraja Thandapani, Panagiotis Ntziachristos, Yohana Ghebrechristos, Sofia Nomikou, Charalampos Lazaris, Xufeng Chen, et al. 2020. “Three-Dimensional Chromatin Landscapes in T Cell Acute Lymphoblastic Leukemia”. Nat Genet 52: 388-400.

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Human U2OS Cells – profiling bioactive compounds using Cell Painting

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Accession number BBBC036 · Version 1 Example images Description of the biological application Phenotypic profiling attempts to summarize multiparametric, feature-based analysis of cellular phenotypes of each sample so that similarities between profiles reflect similarities between samples. This...

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Our CellProfiler software has yielded discoveries in several translational projects, some of which have had a direct impact on the treatment of disease. For example, CellProfiler has been used to identify several small molecules that are effective in treating particular diseases in mouse models. In...

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Meetings Meetings may be conducted in person or by conference call. The Center Chair will notify all members of the place, day, time and purpose for any meeting. Public Q&A Sessions These sessions are open to the public and we encourage school faculty and students to attend. The purpose of these...