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Copper induces cell death by targeting lipoylated TCA cycle proteins

Publication: Journal Article

Tsvetkov, Peter, Shannon Coy, Boryana Petrova, Margaret Dreishpoon, Ana Verma, Mai Abdusamad, Jordan Rossen, et al. 2022. “Copper Induces Cell Death by Targeting Lipoylated TCA Cycle Proteins”. Science 375 (6586): 1254-61.

Customizing a Model for Fiber Segmentation, Part 3: Constructing a CellProfiler Pipeline

Blog: August 05, 2022

Melissa Gillis In the previous two sections of this blogpost I explained how I analyzed multiple methods to segment fluorescent images of collagen IV fibers, and generated accurate segmentation using an ilastik machine learning model. In this section I will explain how I constructed a CellProfiler...

Customizing a Model for Fiber Segmentation, Part 4: Analyzing the Results

Blog: August 05, 2022

Melissa Gillis In the final section of this blogpost series, I will discuss some of the benefits and drawbacks of this model and discuss some of the data I acquired from the images. This model was able to successfully segment the images that were not able to be accurately segmented by Pearl’s...

Sam Chen

Person: Associate Computational Biologist

About Richard N. Merkin, MD

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Janny Liao

Person: Harvard Student/UROP

I am a Harvard student studying Integrative Biology. I am working on identifying genomic mediators driving breast cancer metastasis and therapy resistance.

I2K 2022 Conference - From Images to Knowledge with ImageJ & Friends

News: January 03, 2022

The Center for Open Bioimage Analysis (COBA) at Broad Institute and LOCI UW-Madison, as well as the Fiji development team at Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, is pleased to formally announce the 2022 “From Images to Knowledge with ImageJ & Friends (I2K)”...

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Community’s Input: 2020 BioImage Analysis Survey

Blog: February 08, 2022

Nasim Jamali As creators of open source tools, we spend a lot of time thinking about user needs - what kinds of images people are working with these days, what tools are working well, where the pain points are, and how easy it is to learn how to do any of this in the first place. While things like...

COBA paper on ImageJ and CellProfiler rated #1

News: February 10, 2022

COBA paper on ImageJ and CellProfiler rated #1 in Altmetrics for Best of Current Protocols 2021! ImageJ and CellProfiler: Complements in Open-Source Bioimage Analysis ImageJ and CellProfiler have long been leading open-source platforms in the field of bioimage analysis. ImageJ's traditional strength...