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Expansion in situ genome sequencing links nuclear abnormalities to aberrant chromatin regulation.
Labade, Ajay S, Zachary D Chiang, Caroline Comenho, Paul L Reginato, Andrew C Payne, Andrew S Earl, Rojesh Shrestha, et al. 2025. “Expansion in Situ Genome Sequencing Links Nuclear Abnormalities to Aberrant Chromatin Regulation.”. Science (New York, N.Y.) 389 (6758): eadt2781.
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To nominate individuals and/or teams for the Merkin Prize, please confirm you've reviewed the eligibility requirements and then fill out the nomination form below. FAQs can be viewed here. For additional questions or technical difficulties, contact merkinprize@broadinstitute.org. Nomination Deadline...
Dylan Mercado
Dylan joined the Broad Summer Scholars Program eager to explore how tiny changes in DNA can ripple outward to affect brain function and health. At the Stanley Center, he worked on understanding the functional effects of missense mutations in the CACNA1A gene, which encodes the CaV2.1 calcium channel...
Reproducible single-cell annotation of programs underlying T cell subsets, activation states and functions.
Kotliar, Dylan, Michelle Curtis, Ryan Agnew, Kathryn Weinand, Aparna Nathan, Yuriy Baglaenko, Kamil Slowikowski, et al. 2025. “Reproducible Single-Cell Annotation of Programs Underlying T Cell Subsets, Activation States and Functions.”. Nature Methods.
Modeling heterogeneity in single-cell perturbation states enhances detection of response eQTLs.
Valencia, Cristian, Aparna Nathan, Joyce B Kang, Laurie Rumker, Hyunsun Lee, and Soumya Raychaudhuri. 2025. “Modeling Heterogeneity in Single-Cell Perturbation States Enhances Detection of Response EQTLs.”. Nature Genetics.
Funded Research
Jonathan currently leads a funded research portfolio of over $7 million dollars in data infrastructure and governance grants. He currently serves as the Principal Investigator for the Analysis, Visualization, and Informatics Lab-space (AnVIL) funded by the National Human Genome Research Institute...
Products
Jonathan has led software, data engineering, and operations teams in genomic data sharing for nearly a decade. The development and operation of these projects have served the needs of numerous governments, research programs, labs, and individual researchers - ultimately enabling them to do more...
Enabling Researchers to Quickly Find Useful Controlled-Access Data through View-Only Data Access Requests (VODAR)
Lawson, Jonathan. Working Paper. “Enabling Researchers to Quickly Find Useful Controlled-Access Data through View-Only Data Access Requests (VODAR)”. SSRN, Working Paper.
Leveraging Algorithms to Improve Decision-Making Workflows for Genomic Data Access and Management.
Rahimzadeh, Vasiliki, Jonathan Lawson, Greg Rushton, and Edward S Dove. 2022. “Leveraging Algorithms to Improve Decision-Making Workflows for Genomic Data Access and Management.”. Biopreservation and Biobanking 20 (5): 429-35.