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98 results found

Chromatin complex dependencies reveal targeting opportunities in leukemia.

Publication: Journal Article

Najm, Fadi J, Peter DeWeirdt, Molly M Moore, Samantha M Bevill, Chadi A El Farran, Kevin A Macias, Mudra Hegde, et al. 2023. “Chromatin Complex Dependencies Reveal Targeting Opportunities in Leukemia.”. Nature Communications 14 (1): 448.

Long-range phasing of dynamic, tissue-specific and allele-specific regulatory elements.

Publication: Journal Article

Battaglia, Sofia, Kevin Dong, Jingyi Wu, Zeyu Chen, Fadi J Najm, Yuanyuan Zhang, Molly M Moore, Vivian Hecht, Noam Shoresh, and Bradley E Bernstein. 2022. “Long-Range Phasing of Dynamic, Tissue-Specific and Allele-Specific Regulatory Elements.”. Nature Genetics 54 (10): 1504-13.

Mitochondrial variant enrichment from high-throughput single-cell RNA sequencing resolves clonal populations.

Publication: Journal Article

Miller, Tyler E, Caleb A Lareau, Julia A Verga, Erica A K DePasquale, Vincent Liu, Daniel Ssozi, Katalin Sandor, et al. 2022. “Mitochondrial Variant Enrichment from High-Throughput Single-Cell RNA Sequencing Resolves Clonal Populations.”. Nature Biotechnology 40 (7): 1030-34.

Proper acquisition of cell class identity in organoids allows definition of fate specification programs of the human cerebral cortex.

Publication: Journal Article

Uzquiano, Ana, Amanda J Kedaigle, Martina Pigoni, Bruna Paulsen, Xian Adiconis, Kwanho Kim, Tyler Faits, et al. 2022. “Proper Acquisition of Cell Class Identity in Organoids Allows Definition of Fate Specification Programs of the Human Cerebral Cortex.”. Cell 185 (20): 3770-3788.e27.

Population-scale tissue transcriptomics maps long non-coding RNAs to complex disease.

Publication: Journal Article

de Goede, Olivia M, Daniel C Nachun, Nicole M Ferraro, Michael J Gloudemans, Abhiram S Rao, Craig Smail, Tiffany Y Eulalio, et al. 2021. “Population-Scale Tissue Transcriptomics Maps Long Non-Coding RNAs to Complex Disease.”. Cell 184 (10): 2633-2648.e19.

Kevin Dong

Person:

Computational Associate II, GRO

Robbyn Issner

Person:

Lab Manager, GRO

Jonathan Gootenberg, Ph.D.

Person:

McGovern Fellow, Massachusetts Institute of Technology

Liz Gaskell, Ph.D.

Person:

Director, Operations and Strategy, Epigenomics Program and Gene Regulation Observatory

An unprecedented view of gene regulation

News: May 08, 2023

GRO members Anders Sejr Hansen, together with Viraat Goel and Miles Huseyin from the Hansen lab, talk to Anna Trafton from the MIT news office about their new method - Region Capture Micro-C: An unprecedented view of gene regulation MIT engineers’ new technique analyzes the 3D organization of the...