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NSF BBSRC Imaging Flow Cytometry Project
NSF BBSRC Imaging Flow Cytometry Project (July 15, 2015–June 30, 2018) [ Project abstract at nsf.gov] [Project Outcomes Report (search here, using Fed Award ID 1458626 ( PDF))] Non-technical description of the problem: There are a variety of cell types circulating in human blood, each with distinct...
A metastasis map of human cancer cell lines
Jin, X., Z. Demere, K. Nair, A. Ali, G. B. Ferraro, T. Natoli, A. Deik, et al. 2020. “A Metastasis Map of Human Cancer Cell Lines”. Nature 588: 331-36.
UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia
Kitareewan, S., I. Pitha-Rowe, D. Sekula, C. H. Lowrey, M. J. Nemeth, T. R. Golub, S. J. Freemantle, and E. Dmitrovsky. 2002. “UBE1L Is a Retinoid Target That Triggers PML/RARalpha Degradation and Apoptosis in Acute Promyelocytic Leukemia”. Proc Natl Acad Sci U S A 99: 3806-11.
Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9
Krivtsov, A. V., D. Twomey, Z. Feng, M. C. Stubbs, Y. Wang, J. Faber, J. E. Levine, et al. 2006. “Transformation from Committed Progenitor to Leukaemia Stem Cell Initiated by MLL-AF9”. Nature 442: 818-22.
MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells
Kryukov, G. V., F. H. Wilson, J. R. Ruth, J. Paulk, A. Tsherniak, S. E. Marlow, F. Vazquez, et al. 2016. “MTAP Deletion Confers Enhanced Dependency on the PRMT5 Arginine Methyltransferase in Cancer Cells”. Science 351: 1214-8.
A remarkably simple genome underlies highly malignant pediatric rhabdoid cancers
Lee, R. S., C. Stewart, S. L. Carter, L. Ambrogio, K. Cibulskis, C. Sougnez, M. S. Lawrence, et al. 2012. “A Remarkably Simple Genome Underlies Highly Malignant Pediatric Rhabdoid Cancers”. J Clin Invest 122: 2983-8.
Distinct microRNA expression profiles in acute myeloid leukemia with common translocations
Li, Z., J. Lu, M. Sun, S. Mi, H. Zhang, R. T. Luo, P. Chen, et al. 2008. “Distinct MicroRNA Expression Profiles in Acute Myeloid Leukemia With Common Translocations”. Proc Natl Acad Sci U S A 105: 15535-40.
Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing
Lohr, J. G., P. Stojanov, M. S. Lawrence, D. Auclair, B. Chapuy, C. Sougnez, P. Cruz-Gordillo, et al. 2012. “Discovery and Prioritization of Somatic Mutations in Diffuse Large B-Cell Lymphoma (DLBCL) by Whole-Exome Sequencing”. Proc Natl Acad Sci U S A 109: 3879-84.
MicroRNA expression profiles classify human cancers
Lu, J., G. Getz, E. A. Miska, E. Alvarez-Saavedra, J. Lamb, D. Peck, A. Sweet-Cordero, et al. 2005. “MicroRNA Expression Profiles Classify Human Cancers”. Nature 435: 834-8.