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Human U2OS cells – Small molecule Cell Painting experiment

Accession number BBBC040 · Version 1 Example images Biological application An ideal small-molecule screening library would be enriched in non-redundant bioactive compounds that maximize the performance diversity of the library. The construction of such libraries would be aided by a rapid feedback...

Dr. Richard A. Young

Nuclei of mouse embryonic cells

Accession number BBBC050 · Version 2 Example images Biological application Cell dynamics during the early mouse embryogenesis change spatiotemporally. For understanding the mechanism of this developmental process, imaging cell dynamics by live-cell imaging of fluorescently labeled nuclei and...

Dr. Nikhil Munshi

Cell Painting

The Carpenter lab and Schreiber lab at the Broad Institute of MIT and Harvard developed Cell Painting, a microscopy assay that generates images that reflect cell response to treatments such as drug or genetic perturbations, in high-throughput (at a scale of 100,000+ perturbations). The Carpenter lab...

Kevin Eliceiri named Fellow of the Optical Society of America

COBA's own Dr. Kevin Eliceiri has been named a 2021 Fellow of the Optical Society of America for outstanding research in cellular microenvironment imaging and bio-image informatics. According to the OSA: This distinction was awarded to 118 OSA members, from 24 countries, for their significant...

Research

KIDNEY DISEASE Autosomal dominant MUC1 kidney disease (MKD, also known as ADTKD-MUC1, and formerly called MCKD1) is a rare hereditary renal disease that ultimately requires dialysis or kidney transplantation for patients. For decades, scientists had known the genetic “neighborhood” of the mutation...

James Coleman, B.S.

Before graduating from Northeastern University in May 2020 with a BS in behavioral neuroscience, James was involved in research studying sleep, memory and pharmacology using both neuroimaging and electrophysiological approaches. His undergraduate thesis was on the neurological and behavioral effects...

Abbe Clark

Senior Computational Biologist