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Leveraging advanced segmentation models in CellProfiler with RunCellpose and RunStarDist
Segmentation is an integral step of any bioimage analysis workflow, which involves delineating areas or objects of interest within an image 1 . All the measurements performed on the image, e.g. size, shape, counts, or pixel intensities are then assigned to these segmented areas or objects to...
An autoinhibitory switch of the LSD1 disordered region controls enhancer silencing.
Waterbury, Amanda L, Hui Si Kwok, Ceejay Lee, Domenic N Narducci, Allyson M Freedy, Cindy Su, Shaunak Raval, et al. 2024. “An Autoinhibitory Switch of the LSD1 Disordered Region Controls Enhancer Silencing.”. Molecular Cell 84 (12): 2238-2254.e11.
Dissection of a CTCF topological boundary uncovers principles of enhancer-oncogene regulation.
Kim, Kyung Lock, Gilbert J Rahme, Viraat Y Goel, Chadi A El Farran, Anders S Hansen, and Bradley E Bernstein. 2024. “Dissection of a CTCF Topological Boundary Uncovers Principles of Enhancer-Oncogene Regulation.”. Molecular Cell 84 (7): 1365-1376.e7.
Editor's Note: Androgen-Induced Differentiation and Tumorigenicity of Human Prostate Epithelial Cells
Berger, Raanan, Phillip G. Febbo, Pradip K. Majumder, Jean J. Zhao, Shayan Mukherjee, Sabina Signoretti, Thirza Campbell, et al. 2024. “Editor’s Note: Androgen-Induced Differentiation and Tumorigenicity of Human Prostate Epithelial Cells”. Cancer Research.
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Benedette Cuffari
Heterozygous deletion of the autism-associated gene CHD8 impairs synaptic function through widespread changes in gene expression and chromatin compaction
Shi, Xi. 2021. “Heterozygous Deletion of the Autism-Associated Gene CHD8 Impairs Synaptic Function through Widespread Changes in Gene Expression and Chromatin Compaction”. American Journal of Human Genetics.