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Jason Buenrostro named a 2023 MacArthur Fellow

News: October 04, 2023

Our GRO Co-Director Jason Buenrostro is named in the 2023 cohort of MacArthur Genius Grant Fellows, in recognition of his impact in tool and technology development thus far, and for his ongoing research in gene regulation and cellular function. Check out his MacArthur Foundation bio here, and an...

An autoinhibitory switch of the LSD1 disordered region controls enhancer silencing.

Publication: Journal Article

Waterbury, Amanda L, Hui Si Kwok, Ceejay Lee, Domenic N Narducci, Allyson M Freedy, Cindy Su, Shaunak Raval, et al. 2024. “An Autoinhibitory Switch of the LSD1 Disordered Region Controls Enhancer Silencing.”. Molecular Cell 84 (12): 2238-2254.e11.

Dissection of a CTCF topological boundary uncovers principles of enhancer-oncogene regulation.

Publication: Journal Article

Kim, Kyung Lock, Gilbert J Rahme, Viraat Y Goel, Chadi A El Farran, Anders S Hansen, and Bradley E Bernstein. 2024. “Dissection of a CTCF Topological Boundary Uncovers Principles of Enhancer-Oncogene Regulation.”. Molecular Cell 84 (7): 1365-1376.e7.

Photoselective sequencing: microscopically guided genomic measurements with subcellular resolution.

Publication: Journal Article

Mangiameli, Sarah M, Haiqi Chen, Andrew S Earl, Julie A Dobkin, Daniel Lesman, Jason D Buenrostro, and Fei Chen. 2023. “Photoselective Sequencing: Microscopically Guided Genomic Measurements With Subcellular Resolution.”. Nature Methods 20 (5): 686-94.

A transcription factor atlas of directed differentiation.

Publication: Journal Article

Joung, Julia, Sai Ma, Tristan Tay, Kathryn R Geiger-Schuller, Paul C Kirchgatterer, Vanessa K Verdine, Baolin Guo, et al. 2023. “A Transcription Factor Atlas of Directed Differentiation.”. Cell 186 (1): 209-229.e26.

The EN-TEx resource of multi-tissue personal epigenomes & variant-impact models.

Publication: Journal Article

Rozowsky, Joel, Jiahao Gao, Beatrice Borsari, Yucheng T Yang, Timur Galeev, Gamze Gürsoy, Charles B Epstein, et al. 2023. “The EN-TEx Resource of Multi-Tissue Personal Epigenomes & Variant-Impact Models.”. Cell 186 (7): 1493-1511.e40.

Human genetic diversity alters off-target outcomes of therapeutic gene editing.

Publication: Journal Article

Cancellieri, Samuele, Jing Zeng, Linda Yingqi Lin, Manuel Tognon, My Anh Nguyen, Jiecong Lin, Nicola Bombieri, et al. 2023. “Human Genetic Diversity Alters Off-Target Outcomes of Therapeutic Gene Editing.”. Nature Genetics 55 (1): 34-43.

Chromatin Potential Identified by Shared Single-Cell Profiling of RNA and Chromatin.

Publication: Journal Article

Ma, Sai, Bing Zhang, Lindsay M LaFave, Andrew S Earl, Zachary Chiang, Yan Hu, Jiarui Ding, et al. 2020. “Chromatin Potential Identified by Shared Single-Cell Profiling of RNA and Chromatin.”. Cell 183 (4): 1103-1116.e20.

Recruiting

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Labs within the GRO are often hiring! Check out each GRO Investigator's profile to find a link to their lab page for more information. The team based at the Broad Institute is often hiring as well. You can search for open positions here.

GRO members Ardlie, Bernstein, Chen, and Buenrostro to contribute to the SMaHT common fund program

News: May 01, 2023

The Somatic Mosaicism across Human Tissues (SMaHT) Network aims to transform our understanding of how somatic mosaicism in human cells influences biology and disease. GRO members Kristin Ardlie, Jason Buenrostro, Fei Chen, and Bradley Bernstein (and their collaborators) were all awarded grants in...