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Seungmin "Sam" Hwang

Person: Principal Investigator

Seungmin “Sam” Hwang is a senior translation group leader within the Center for Integrated Solutions for Infectious Diseases ( CISID) at the Broad Institute of MIT and Harvard. Hwang joined the Broad Institute in September 2023, and the focus of his research is to elucidate the mechanisms of organ...

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.

Publication: Journal Article

Klionsky, Daniel J, Amal Kamal Abdel-Aziz, Sara Abdelfatah, Mahmoud Abdellatif, Asghar Abdoli, Steffen Abel, Hagai Abeliovich, et al. 2021. “Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (4th Edition)1.”. Autophagy 17 (1): 1-382.

Dynamin-related Irgm proteins modulate LPS-induced caspase-11 activation and septic shock.

Publication: Journal Article

Finethy, Ryan, Jacob Dockterman, Miriam Kutsch, Nichole Orench-Rivera, Graham D Wallace, Anthony S Piro, Sarah Luoma, et al. 2020. “Dynamin-Related Irgm Proteins Modulate LPS-Induced Caspase-11 Activation and Septic Shock.”. EMBO Reports 21 (11): e50830.

Nucleotide triphosphatase and RNA chaperone activities of murine norovirus NS3.

Publication: Journal Article

Han, Kang Rok, Ji-Hye Lee, Giri Gowda Kotiguda, Kyoung Ho Jung, Mi Sook Chung, Soowon Kang, Seungmin Hwang, and Kyung Hyun Kim. 2018. “Nucleotide Triphosphatase and RNA Chaperone Activities of Murine Norovirus NS3.”. The Journal of General Virology 99 (11): 1482-93.

Partners in anti-crime: how interferon-inducible GTPases and autophagy proteins team up in cell-intrinsic host defense.

Publication: Journal Article

Coers, Jörn, Hailey M Brown, Seungmin Hwang, and Gregory A Taylor. 2018. “Partners in Anti-Crime: How Interferon-Inducible GTPases and Autophagy Proteins Team up in Cell-Intrinsic Host Defense.”. Current Opinion in Immunology 54: 93-101.

Demarcation of Viral Shelters Results in Destruction by Membranolytic GTPases: Antiviral Function of Autophagy Proteins and Interferon-Inducible GTPases.

Publication: Journal Article

Brown, Hailey M, Scott B Biering, Allen Zhu, Jayoung Choi, and Seungmin Hwang. 2018. “Demarcation of Viral Shelters Results in Destruction by Membranolytic GTPases: Antiviral Function of Autophagy Proteins and Interferon-Inducible GTPases.”. BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology 40 (6): e1700231.

Regulation of cell proliferation and migration by p62 through stabilization of Twist1.

Publication: Journal Article

Qiang, Lei, Baozhong Zhao, Mei Ming, Ning Wang, Tong-Chuan He, Seungmin Hwang, Andrew Thorburn, and Yu-Ying He. 2014. “Regulation of Cell Proliferation and Migration by P62 through Stabilization of Twist1.”. Proceedings of the National Academy of Sciences of the United States of America 111 (25): 9241-6.

Murine norovirus: propagation, quantification, and genetic manipulation.

Publication: Journal Article

Hwang, Seungmin, Bader Alhatlani, Armando Arias, Sarah L Caddy, Constantina Christodoulou, Juliana Bragazza Cunha, Ed Emmott, et al. 2014. “Murine Norovirus: Propagation, Quantification, and Genetic Manipulation.”. Current Protocols in Microbiology 33: 15K.2.1-61.

mRNA display design of fibronectin-based intrabodies that detect and inhibit severe acute respiratory syndrome coronavirus nucleocapsid protein.

Publication: Journal Article

Liao, Hsiang-I, Anders Olson, Seungmin Hwang, Hongyu Deng, Elaine Wong, Ralph S Baric, Richard W Roberts, and Ren Sun. 2009. “MRNA Display Design of Fibronectin-Based Intrabodies That Detect and Inhibit Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Protein.”. The Journal of Biological Chemistry 284 (26): 17512-20.

A repetitive region of gammaherpesvirus genomic DNA is a ligand for induction of type I interferon.

Publication: Journal Article

Sanchez, David Jesse, Daniel Miranda, Vaithilingaraja Arumugaswami, Seungmin Hwang, Adam E Singer, Ashkon Senaati, Arash Shahangian, Moon Jung Song, Ren Sun, and Genhong Cheng. 2008. “A Repetitive Region of Gammaherpesvirus Genomic DNA Is a Ligand for Induction of Type I Interferon.”. Journal of Virology 82 (5): 2208-17.