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103 results found

An autoinhibitory switch of the LSD1 disordered region controls enhancer silencing.

Publication: Journal Article

Waterbury, Amanda L, Hui Si Kwok, Ceejay Lee, Domenic N Narducci, Allyson M Freedy, Cindy Su, Shaunak Raval, et al. 2024. “An Autoinhibitory Switch of the LSD1 Disordered Region Controls Enhancer Silencing.”. Molecular Cell 84 (12): 2238-2254.e11.

Dissection of a CTCF topological boundary uncovers principles of enhancer-oncogene regulation.

Publication: Journal Article

Kim, Kyung Lock, Gilbert J Rahme, Viraat Y Goel, Chadi A El Farran, Anders S Hansen, and Bradley E Bernstein. 2024. “Dissection of a CTCF Topological Boundary Uncovers Principles of Enhancer-Oncogene Regulation.”. Molecular Cell 84 (7): 1365-1376.e7.

Vijay Sankaran, M.D., Ph.D.

Person:

Jan Ellen Paradise, MD Professor of Pediatrics, Harvard Medical School Investigator, Howard Hughes Medical Institute Attending Physician, Dana-Farber/Boston Children's Cancer and Blood Disorders Center

Expansion in situ genome sequencing links nuclear abnormalities to aberrant chromatin regulation.

Publication: Journal Article

Labade, Ajay S, Zachary D Chiang, Caroline Comenho, Paul L Reginato, Andrew C Payne, Andrew S Earl, Rojesh Shrestha, et al. 2025. “Expansion in Situ Genome Sequencing Links Nuclear Abnormalities to Aberrant Chromatin Regulation.”. Science (New York, N.Y.) 389 (6758): eadt2781.

Photoselective sequencing: microscopically guided genomic measurements with subcellular resolution.

Publication: Journal Article

Mangiameli, Sarah M, Haiqi Chen, Andrew S Earl, Julie A Dobkin, Daniel Lesman, Jason D Buenrostro, and Fei Chen. 2023. “Photoselective Sequencing: Microscopically Guided Genomic Measurements With Subcellular Resolution.”. Nature Methods 20 (5): 686-94.

A transcription factor atlas of directed differentiation.

Publication: Journal Article

Joung, Julia, Sai Ma, Tristan Tay, Kathryn R Geiger-Schuller, Paul C Kirchgatterer, Vanessa K Verdine, Baolin Guo, et al. 2023. “A Transcription Factor Atlas of Directed Differentiation.”. Cell 186 (1): 209-229.e26.

The EN-TEx resource of multi-tissue personal epigenomes & variant-impact models.

Publication: Journal Article

Rozowsky, Joel, Jiahao Gao, Beatrice Borsari, Yucheng T Yang, Timur Galeev, Gamze Gürsoy, Charles B Epstein, et al. 2023. “The EN-TEx Resource of Multi-Tissue Personal Epigenomes & Variant-Impact Models.”. Cell 186 (7): 1493-1511.e40.

Human genetic diversity alters off-target outcomes of therapeutic gene editing.

Publication: Journal Article

Cancellieri, Samuele, Jing Zeng, Linda Yingqi Lin, Manuel Tognon, My Anh Nguyen, Jiecong Lin, Nicola Bombieri, et al. 2023. “Human Genetic Diversity Alters Off-Target Outcomes of Therapeutic Gene Editing.”. Nature Genetics 55 (1): 34-43.

Chromatin Potential Identified by Shared Single-Cell Profiling of RNA and Chromatin.

Publication: Journal Article

Ma, Sai, Bing Zhang, Lindsay M LaFave, Andrew S Earl, Zachary Chiang, Yan Hu, Jiarui Ding, et al. 2020. “Chromatin Potential Identified by Shared Single-Cell Profiling of RNA and Chromatin.”. Cell 183 (4): 1103-1116.e20.

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