Gene expression-based screening for inhibitors of PDGFR signaling
Antipova, A. A., B. R. Stockwell, and T. R. Golub. 2008. “Gene Expression-Based Screening for Inhibitors of PDGFR Signaling”. Genome Biol 9: R47.
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The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease
Lamb, J., E. D. Crawford, D. Peck, J. W. Modell, I. C. Blat, M. J. Wrobel, J. Lerner, et al. 2006. “The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease”. Science 313: 1929-35.
Discovery and saturation analysis of cancer genes across 21 tumour types
Lawrence, M. S., P. Stojanov, C. H. Mermel, J. T. Robinson, L. A. Garraway, T. R. Golub, M. Meyerson, S. B. Gabriel, E. S. Lander, and G. Getz. 2014. “Discovery and Saturation Analysis of Cancer Genes across 21 Tumour Types”. Nature 505: 495-501.
Whole-exome sequencing of circulating tumor cells provides a window into metastatic prostate cancer
Lohr, J. G., V. A. Adalsteinsson, K. Cibulskis, A. D. Choudhury, M. Rosenberg, P. Cruz-Gordillo, J. M. Francis, et al. 2014. “Whole-Exome Sequencing of Circulating Tumor Cells Provides a Window into Metastatic Prostate Cancer”. Nat Biotechnol 32: 479-84.
Widespread genetic heterogeneity in multiple myeloma: implications for targeted therapy
Lohr, J. G., P. Stojanov, S. L. Carter, P. Cruz-Gordillo, M. S. Lawrence, D. Auclair, C. Sougnez, et al. 2014. “Widespread Genetic Heterogeneity in Multiple Myeloma: Implications for Targeted Therapy”. Cancer Cell 25: 91-101.
Highly parallel identification of essential genes in cancer cells
Luo, B., H. W. Cheung, A. Subramanian, T. Sharifnia, M. Okamoto, X. Yang, G. Hinkle, et al. 2008. “Highly Parallel Identification of Essential Genes in Cancer Cells”. Proc Natl Acad Sci U S A 105: 20380-5.
mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways
Majumder, P. K., P. G. Febbo, R. Bikoff, R. Berger, Q. Xue, L. M. McMahon, J. Manola, et al. 2004. “MTOR Inhibition Reverses Akt-Dependent Prostate Intraepithelial Neoplasia through Regulation of Apoptotic and HIF-1-Dependent Pathways”. Nat Med 10: 594-601.
Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability
McGill, G. G., M. Horstmann, H. R. Widlund, J. Du, G. Motyckova, E. K. Nishimura, Y. L. Lin, et al. 2002. “Bcl2 Regulation by the Melanocyte Master Regulator Mitf Modulates Lineage Survival and Melanoma Cell Viability”. Cell 109: 707-18.
Computational correction of copy number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells
Meyers, R. M., J. G. Bryan, J. M. McFarland, B. A. Weir, A. E. Sizemore, H. Xu, N. V. Dharia, et al. 2017. “Computational Correction of Copy Number Effect Improves Specificity of CRISPR-Cas9 Essentiality Screens in Cancer Cells”. Nat Genet 49: 1779-84.
Erratum: The microRNA miR-31 inhibits CD8(+) T cell function in chronic viral infection
Moffett, H. F., A. N. R. Cartwright, H. J. Kim, J. Godec, J. Pyrdol, T. Aijo, G. J. Martinez, et al. 2017. “Erratum: The MicroRNA MiR-31 Inhibits CD8(+) T Cell Function in Chronic Viral Infection”. Nat Immunol 18: 1173.