BRAF mutation predicts sensitivity to MEK inhibition
Solit, D. B., L. A. Garraway, C. A. Pratilas, A. Sawai, G. Getz, A. Basso, Q. Ye, et al. 2006. “BRAF Mutation Predicts Sensitivity to MEK Inhibition”. Nature 439: 358-62.
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Drug and disease signature integration identifies synergistic combinations in glioblastoma
Stathias, V., A. M. Jermakowicz, M. E. Maloof, M. Forlin, W. Walters, R. K. Suter, M. A. Durante, et al. 2018. “Drug and Disease Signature Integration Identifies Synergistic Combinations in Glioblastoma”. Nat Commun 9: 5315.
Chemosensitivity prediction by transcriptional profiling
Staunton, J. E., D. K. Slonim, H. A. Coller, P. Tamayo, M. J. Angelo, J. Park, U. Scherf, et al. 2001. “Chemosensitivity Prediction by Transcriptional Profiling”. Proc Natl Acad Sci U S A 98: 10787-92.
Signature-based small molecule screening identifies cytosine arabinoside as an EWS/FLI modulator in Ewing sarcoma
Stegmaier, K., J. S. Wong, K. N. Ross, K. T. Chow, D. Peck, R. D. Wright, S. L. Lessnick, A. L. Kung, and T. R. Golub. 2007. “Signature-Based Small Molecule Screening Identifies Cytosine Arabinoside As an EWS/FLI Modulator in Ewing Sarcoma”. PLoS Med 4: e122.
Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion
Straussman, R., T. Morikawa, K. Shee, M. Barzily-Rokni, Z. R. Qian, J. Du, A. Davis, et al. 2012. “Tumour Micro-Environment Elicits Innate Resistance to RAF Inhibitors through HGF Secretion”. Nature 487: 500-4.
TEL is one of the targets for deletion on 12p in many cases of childhood B-lineage acute lymphoblastic leukemia
Takeuchi, S., T. Seriu, C. R. Bartram, T. R. Golub, A. Reiter, I. Miyoshi, D. G. Gilliland, and H. P. Koeffler. 1997. “TEL Is One of the Targets for Deletion on 12p in Many Cases of Childhood B-Lineage Acute Lymphoblastic Leukemia”. Leukemia 11: 1220-3.
Occurrence of TEL-AML1 fusion resulting from (12;21) translocation in human early B-lineage leukemia cell lines
Uphoff, C. C., R. A. MacLeod, S. A. Denkmann, T. R. Golub, A. Borkhardt, J. W. Janssen, and H. G. Drexler. 1997. “Occurrence of TEL-AML1 Fusion Resulting from (12;21) Translocation in Human Early B-Lineage Leukemia Cell Lines”. Leukemia 11: 441-7.
Expression profiling of archival tumors for long-term health studies
Waldron, L., S. Ogino, Y. Hoshida, K. Shima, A. E. McCart Reed, P. T. Simpson, Y. Baba, et al. 2012. “Expression Profiling of Archival Tumors for Long-Term Health Studies”. Clin Cancer Res 18: 6136-46.
Yolk sac angiogenic defect and intra-embryonic apoptosis in mice lacking the Ets-related factor TEL
Wang, L. C., F. Kuo, Y. Fujiwara, D. G. Gilliland, T. R. Golub, and S. H. Orkin. 1997. “Yolk Sac Angiogenic Defect and Intra-Embryonic Apoptosis in Mice Lacking the Ets-Related Factor TEL”. EMBO J 16: 4374-83.
The TEL/ETV6 gene is required specifically for hematopoiesis in the bone marrow
Wang, L. C., W. Swat, Y. Fujiwara, L. Davidson, J. Visvader, F. Kuo, F. W. Alt, D. G. Gilliland, T. R. Golub, and S. H. Orkin. 1998. “The TEL/ETV6 Gene Is Required Specifically for Hematopoiesis in the Bone Marrow”. Genes Dev 12: 2392-402.