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Congyi Lu, MD/Ph.D.
Todd Golub
Todd Golub is director of the Broad Institute of MIT and Harvard, and a founding core member of the institute. He is also a member of the faculty of the Dana-Farber Cancer Institute and Harvard Medical School. Golub is a world-renowned physician-scientist who pioneered the application of genomics to...
Funding
A metastasis map of human cancer cell lines
Jin, X., Z. Demere, K. Nair, A. Ali, G. B. Ferraro, T. Natoli, A. Deik, et al. 2020. “A Metastasis Map of Human Cancer Cell Lines”. Nature 588: 331-36.
UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia
Kitareewan, S., I. Pitha-Rowe, D. Sekula, C. H. Lowrey, M. J. Nemeth, T. R. Golub, S. J. Freemantle, and E. Dmitrovsky. 2002. “UBE1L Is a Retinoid Target That Triggers PML/RARalpha Degradation and Apoptosis in Acute Promyelocytic Leukemia”. Proc Natl Acad Sci U S A 99: 3806-11.
Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9
Krivtsov, A. V., D. Twomey, Z. Feng, M. C. Stubbs, Y. Wang, J. Faber, J. E. Levine, et al. 2006. “Transformation from Committed Progenitor to Leukaemia Stem Cell Initiated by MLL-AF9”. Nature 442: 818-22.
MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells
Kryukov, G. V., F. H. Wilson, J. R. Ruth, J. Paulk, A. Tsherniak, S. E. Marlow, F. Vazquez, et al. 2016. “MTAP Deletion Confers Enhanced Dependency on the PRMT5 Arginine Methyltransferase in Cancer Cells”. Science 351: 1214-8.
A remarkably simple genome underlies highly malignant pediatric rhabdoid cancers
Lee, R. S., C. Stewart, S. L. Carter, L. Ambrogio, K. Cibulskis, C. Sougnez, M. S. Lawrence, et al. 2012. “A Remarkably Simple Genome Underlies Highly Malignant Pediatric Rhabdoid Cancers”. J Clin Invest 122: 2983-8.