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Cici Shi, PhD
Congyi Lu, MD/Ph.D.
Funding
Todd Golub
Todd Golub is director of the Broad Institute of MIT and Harvard, and a founding core member of the institute. He is also a member of the faculty of the Dana-Farber Cancer Institute and Harvard Medical School. Golub is a world-renowned physician-scientist who pioneered the application of genomics to...
Genomic evolution of cancer models: perils and opportunities
Ben-David, U., R. Beroukhim, and T. R. Golub. 2019. “Genomic Evolution of Cancer Models: Perils and Opportunities”. Nat Rev Cancer 19: 97-109.
A dataset of images and morphological profiles of 30 000 small-molecule treatments using the Cell Painting assay
Bray, M. A., S. M. Gustafsdottir, M. H. Rohban, S. Singh, V. Ljosa, K. L. Sokolnicki, J. A. Bittker, et al. 2017. “A Dataset of Images and Morphological Profiles of 30 000 Small-Molecule Treatments Using the Cell Painting Assay”. Gigascience 6: 1-5.
WRN helicase is a synthetic lethal target in microsatellite unstable cancers
Chan, E. M., T. Shibue, J. M. McFarland, B. Gaeta, M. Ghandi, N. Dumont, A. Gonzalez, et al. 2019. “WRN Helicase Is a Synthetic Lethal Target in Microsatellite Unstable Cancers”. Nature 568: 551-56.
CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2
Chen, L., G. Alexe, N. V. Dharia, L. Ross, A. B. Iniguez, A. S. Conway, E. J. Wang, et al. 2018. “CRISPR-Cas9 Screen Reveals a MYCN-Amplified Neuroblastoma Dependency on EZH2”. J Clin Invest 128: 446-62.