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Nuclei of mouse embryonic cells
Accession number BBBC050 · Version 2 Example images Biological application Cell dynamics during the early mouse embryogenesis change spatiotemporally. For understanding the mechanism of this developmental process, imaging cell dynamics by live-cell imaging of fluorescently labeled nuclei and...
Dr. Nikhil Munshi
Community Enagagment
COBA’s mission is to catalyze the entire bioimage analysis software community. What have we accomplished thus far? Scientific Community Image Forum We created and sponsor the Scientific Community Image Forum. This forum has brought together dozens of open source image analysis platforms to one...
Three-dimensional Chromatin Landscapes in T cell Acute Lymphoblastic Leukemia
Kloetgen, Andreas, Palaniraja Thandapani, Panagiotis Ntziachristos, Yohana Ghebrechristos, Sofia Nomikou, Charalampos Lazaris, Xufeng Chen, et al. 2020. “Three-Dimensional Chromatin Landscapes in T Cell Acute Lymphoblastic Leukemia”. Nat Genet 52: 388-400.
Cell Cycle Jurkat Cells
Accession number BBBC048 · Version 1 Example images Biological application Abstract: We show that deep convolutional neural networks combined with nonlinear dimension reduction enable reconstructing biological processes based on raw image data. We demonstrate this by reconstructing the cell cycle of...
Oncogenic Hijacking of the Stress Response Machinery in T cell Acute Lymphoblastic Leukemia
Kourtis, Nikos, Charalampos Lazaris, Kathryn Hockemeyer, Juan Carlos Balandrán, Alejandra R. Jimenez, Jasper Mullenders, Yixiao Gong, et al. 2018. “Oncogenic Hijacking of the Stress Response Machinery in T Cell Acute Lymphoblastic Leukemia”. Nat Med 24: 1157-66.
Stratification of TAD Boundaries Reveals Preferential Insulation of Super-enhancers by Strong Boundaries
Gong, Yixiao, Charalampos Lazaris, Theodore Sakellaropoulos, Aurelie Lozano, Prabhanjan Kambadur, Panagiotis Ntziachristos, Iannis Aifantis, and Aristotelis Tsirigos. 2018. “Stratification of TAD Boundaries Reveals Preferential Insulation of Super-Enhancers by Strong Boundaries”. Nat Commun 9: 542-42.
Low-Grade Astrocytoma Mutations in IDH1, P53, and ATRX Cooperate to Block Differentiation of Human Neural Stem Cells via Repression of SOX2
Modrek, Aram S., Danielle Golub, Themasap Khan, Devin Bready, Jod Prado, Christopher Bowman, Jingjing Deng, et al. 2017. “Low-Grade Astrocytoma Mutations in IDH1, P53, and ATRX Cooperate to Block Differentiation of Human Neural Stem Cells via Repression of SOX2”. Cell Rep 21: 1267-80.
Regulation of Transcriptional Elongation in Pluripotency and cell Differentiation by the PHD-finger Protein Phf5a
Strikoudis, Alexandros, Charalampos Lazaris, Thomas Trimarchi, Antonio L. Galvao Neto, Yan Yang, Panagiotis Ntziachristos, Scott Rothbart, et al. 2016. “Regulation of Transcriptional Elongation in Pluripotency and Cell Differentiation by the PHD-Finger Protein Phf5a”. Nat Cell Biol 18: 1127-38.