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Role of Dysregulated Cytokine Signaling and Bacterial Triggers in the Pathogenesis of Cutaneous T-Cell Lymphoma

Publication: Journal Article

Fanok, Melania H., Amy Sun, Laura K. Fogli, Vijay Narendran, Miriam Eckstein, Kasthuri Kannan, Igor Dolgalev, et al. 2018. “Role of Dysregulated Cytokine Signaling and Bacterial Triggers in the Pathogenesis of Cutaneous T-Cell Lymphoma”. J Invest Dermatol 138: 1116-25.

FBXW7 Modulates Cellular Stress Response and Metastatic Potential Through HSF1 Post-translational Modification

Publication: Journal Article

Kourtis, Nikos, Rana S. Moubarak, Beatriz Aranda-Orgilles, Kevin Lui, Iraz T. Aydin, Thomas Trimarchi, Farbod Darvishian, et al. 2015. “FBXW7 Modulates Cellular Stress Response and Metastatic Potential Through HSF1 Post-Translational Modification”. Nat Cell Biol 17: 322-32.

Human U2OS cells – Small molecule Cell Painting experiment

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Accession number BBBC040 · Version 1 Example images Biological application An ideal small-molecule screening library would be enriched in non-redundant bioactive compounds that maximize the performance diversity of the library. The construction of such libraries would be aided by a rapid feedback...

2022 Dates Announced: From Images to Knowledge with ImageJ & Friends (I2K)

News: August 18, 2020

Originally slated for Fall of 2020, we are excited to announce new dates for the "From Images to Knowledge with ImageJ & Friends (I2K)" conference: Sept 23-24, 2021 May 9-10, 2022! Watch here for more info.

Dr. Richard A. Young

Person: Institute Member, Whitehead Institute for Biomedical Research, Professor of Biology, Massachusetts Institute of Technology

Nuclei of mouse embryonic cells

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Accession number BBBC050 · Version 2 Example images Biological application Cell dynamics during the early mouse embryogenesis change spatiotemporally. For understanding the mechanism of this developmental process, imaging cell dynamics by live-cell imaging of fluorescently labeled nuclei and...

Dr. Nikhil Munshi

Person: Professor of Medicine, Harvard Medical School, Director of Basic and Correlative Science, Jerome Lipper Multiple Myeloma Center

Community Enagagment

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COBA’s mission is to catalyze the entire bioimage analysis software community. What have we accomplished thus far? Scientific Community Image Forum We created and sponsor the Scientific Community Image Forum. This forum has brought together dozens of open source image analysis platforms to one...

Extent and Context Dependence of Pleiotropy Revealed by High-throughput Single-cell Phenotyping

Publication: Journal Article

Geiler-Samerotte, Kerry A., Shuang Li, Charalampos Lazaris, Austin Taylor, Naomi Ziv, Chelsea Ramjeawan, Annalise B. Paaby, and Mark L. Siegal. 2020. “Extent and Context Dependence of Pleiotropy Revealed by High-Throughput Single-Cell Phenotyping”. PLoS Biol 18: e3000836-e3000836.

Opposing Functions of H2BK120 Ubiquitylation and H3K79 Methylation in the Regulation of Pluripotency by the Paf1 Complex

Publication: Journal Article

Strikoudis, Alexandros, Charalampos Lazaris, Panagiotis Ntziachristos, Aristotelis Tsirigos, and Iannis Aifantis. 2017. “Opposing Functions of H2BK120 Ubiquitylation and H3K79 Methylation in the Regulation of Pluripotency by the Paf1 Complex”. Cell Cycle 16: 2315-22.