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Our Mission The audacious goal of the GRO is to build an atlas of the function of every base in the non-coding genome. We believe that achieving this goal will accelerate all aspects of genomic medicine by underpinning efforts to: understand the function of disease-associated variants, generate new...

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Melina Claussnitzer, PhD

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Associate Director of Scientific Strategy, Novo Nordisk Foundation Center, Broad Institute Co-Director, Type 2 Diabetes Systems Genomics Initiative, Broad Institute Assistant Professor, Harvard Medical School & Beth Israel Deaconess Medical Center Investigator, Center for Genomic Medicine and...

The neuronal pentraxin Nptx2 regulates complement activity and restrains microglia-mediated synapse loss in neurodegeneration.

Publication: Journal Article

Zhou, Jiechao, Sarah D Wade, David Graykowski, Mei-Fang Xiao, Binhui Zhao, Lucia A A Giannini, Jesse E Hanson, et al. 2023. “The Neuronal Pentraxin Nptx2 Regulates Complement Activity and Restrains Microglia-Mediated Synapse Loss in Neurodegeneration.”. Science Translational Medicine 15 (689): eadf0141.

Regulation of purine metabolism connects KCTD13 to a metabolic disorder with autistic features.

Publication: Journal Article

Madison, Jon M, Karen Duong, Ellen F Vieux, Namrata D Udeshi, Sumaiya Iqbal, Elise Requadt, Shaunt Fereshetian, et al. 2021. “Regulation of Purine Metabolism Connects KCTD13 to a Metabolic Disorder With Autistic Features.”. IScience 24 (1): 101935.

PCDH7 interacts with GluN1 and regulates dendritic spine morphology and synaptic function.

Publication: Journal Article

Wang, Yuanyuan, Meghan Kerrisk Campbell, Irene Tom, Oded Foreman, Jesse E Hanson, and Morgan Sheng. 2020. “PCDH7 Interacts With GluN1 and Regulates Dendritic Spine Morphology and Synaptic Function.”. Scientific Reports 10 (1): 10951.

Degradation of postsynaptic scaffold GKAP and regulation of dendritic spine morphology by the TRIM3 ubiquitin ligase in rat hippocampal neurons.

Publication: Journal Article

Hung, Albert Y, Clifford C Sung, Ilana L Brito, and Morgan Sheng. 2010. “Degradation of Postsynaptic Scaffold GKAP and Regulation of Dendritic Spine Morphology by the TRIM3 Ubiquitin Ligase in Rat Hippocampal Neurons.”. PloS One 5 (3): e9842.

Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132.

Publication: Journal Article

Edbauer, Dieter, Joel R Neilson, Kelly A Foster, Chi-Fong Wang, Daniel P Seeburg, Matthew N Batterton, Tomoko Tada, Bridget M Dolan, Phillip A Sharp, and Morgan Sheng. 2010. “Regulation of Synaptic Structure and Function by FMRP-Associated MicroRNAs MiR-125b and MiR-132.”. Neuron 65 (3): 373-84.

The postsynaptic density.

Publication: Journal Article

Kim, Eunjoon, and Morgan Sheng. 2009. “The Postsynaptic Density.”. Current Biology : CB 19 (17): R723-4.

Trans-synaptic adhesion between NGL-3 and LAR regulates the formation of excitatory synapses.

Publication: Journal Article

Woo, Jooyeon, Seok-Kyu Kwon, Seungwon Choi, Seho Kim, Jae-Ran Lee, Anthone W Dunah, Morgan Sheng, and Eunjoon Kim. 2009. “Trans-Synaptic Adhesion Between NGL-3 and LAR Regulates the Formation of Excitatory Synapses.”. Nature Neuroscience 12 (4): 428-37.