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Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function.

Publication: Journal Article

Hackos, David H, Patrick J Lupardus, Teddy Grand, Yelin Chen, Tzu-Ming Wang, Paul Reynen, Amy Gustafson, et al. 2016. “Positive Allosteric Modulators of GluN2A-Containing NMDARs With Distinct Modes of Action and Impacts on Circuit Function.”. Neuron 89 (5): 983-99.

Local pruning of dendrites and spines by caspase-3-dependent and proteasome-limited mechanisms.

Publication: Journal Article

Ertürk, Ali, Yuanyuan Wang, and Morgan Sheng. 2014. “Local Pruning of Dendrites and Spines by Caspase-3-Dependent and Proteasome-Limited Mechanisms.”. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience 34 (5): 1672-88.

Long-term depression: a cell biological view.

Publication: Journal Article

Sheng, Morgan, and Ali Ertürk. 2014. “Long-Term Depression: A Cell Biological View.”. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 369 (1633): 20130138.

Caspases in synaptic plasticity.

Publication: Journal Article

Li, Zheng, and Morgan Sheng. 2012. “Caspases in Synaptic Plasticity.”. Molecular Brain 5: 15.

JUMP Cell Painting protocol (v3) in press

News: December 01, 2022

The newly optimized version 3 of the protocol has been accepted! It is in press at Nature Protocols as Cimini et al. 2023.

Two publicly available portals to explore the data

News: March 28, 2023

Ardigen’s phenAID portal The phenAID JUMP-CP Explorer was created by the Ardigen Data Science and Software Development team to enable easy access and visualization of JUMP-CP data. The web-based application shows a phenotypic and structural representation of the data set colored by clusters. Users...

Data release & Manuscript in BioRxiv

News: March 28, 2023

We are excited to share that the JUMP Cell Painting Datasets now include most data components from all but one of the sources for the principal dataset (cpg0016), covering 116,000 chemical and over 20,000 genetic perturbations (covering ~15,000 genes). The first draft of metadata files are available...

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Blog: April 18, 2023

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Blog: April 18, 2023

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