Brady Walker
Project Coordinator, GRO and dGTEx
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Inaugural Merkin Prize in Biomedical Technology awarded to Dr. Marvin Caruthers for developing technology that efficiently synthesizes DNA
CONTACT Sarah Farris sarah@comsint.com VIDEO Link The $400,000 award recognizes the far-reaching medical impact of Dr. Caruthers’ development, in the early 1980s, of an efficient and fast method to synthesize nucleic acids. Cambridge, MA (June 28, 2023)—Dr. Marvin H. Caruthers of the University of...
Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma
Hofman, Damon A., Jorge Ruiz-Orera, Ian Yannuzzi, Rakesh Murugesan, Adam Brown, Karl R. Clauser, Alexandra L. Condurat, et al. 2023. “Translation of Non-Canonical Open Reading Frames As a Cancer Cell Survival Mechanism in Childhood Medulloblastoma”. BioRxiv.
Base editor scanning charts the DNMT3A activity landscape.
Lue, Nicholas Z, Emma M Garcia, Kevin C Ngan, Ceejay Lee, John G Doench, and Brian B Liau. 2023. “Base Editor Scanning Charts the DNMT3A Activity Landscape.”. Nature Chemical Biology 19 (2): 176-86.
CRISPR-suppressor scanning reveals a nonenzymatic role of LSD1 in AML.
Vinyard, Michael E, Cindy Su, Allison P Siegenfeld, Amanda L Waterbury, Allyson M Freedy, Pallavi M Gosavi, Yongho Park, et al. 2019. “CRISPR-Suppressor Scanning Reveals a Nonenzymatic Role of LSD1 in AML.”. Nature Chemical Biology 15 (5): 529-39.
GRAFIMO: Variant and haplotype aware motif scanning on pangenome graphs.
Tognon, Manuel, Vincenzo Bonnici, Erik Garrison, Rosalba Giugno, and Luca Pinello. 2021. “GRAFIMO: Variant and Haplotype Aware Motif Scanning on Pangenome Graphs.”. PLoS Computational Biology 17 (9): e1009444.
Screening thousands of transcribed coding and non-coding regions reveals sequence determinants of RNA polymerase II elongation potential.
Vlaming, Hanneke, Claudia A Mimoso, Andrew R Field, Benjamin J E Martin, and Karen Adelman. 2022. “Screening Thousands of Transcribed Coding and Non-Coding Regions Reveals Sequence Determinants of RNA Polymerase II Elongation Potential.”. Nature Structural & Molecular Biology 29 (6): 613-20.
Region Capture Micro-C reveals coalescence of enhancers and promoters into nested microcompartments.
Goel, Viraat Y, Miles K Huseyin, and Anders S Hansen. 2023. “Region Capture Micro-C Reveals Coalescence of Enhancers and Promoters into Nested Microcompartments.”. Nature Genetics 55 (6): 1048-56.
Transcriptome variation in human tissues revealed by long-read sequencing.
Glinos, Dafni A, Garrett Garborcauskas, Paul Hoffman, Nava Ehsan, Lihua Jiang, Alper Gokden, Xiaoguang Dai, et al. 2022. “Transcriptome Variation in Human Tissues Revealed by Long-Read Sequencing.”. Nature 608 (7922): 353-59.
Cell type-specific genetic regulation of gene expression across human tissues.
Kim-Hellmuth, Sarah, François Aguet, Meritxell Oliva, Manuel Muñoz-Aguirre, Silva Kasela, Valentin Wucher, Stephane E Castel, et al. 2020. “Cell Type-Specific Genetic Regulation of Gene Expression across Human Tissues.”. Science (New York, N.Y.) 369 (6509).