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Congrats to Jose Diego, Vijay and team on the publication of their tour de force base editing paper in Cell!
Massively parallel base editing to map variant effects in human hematopoiesis. Martin-Rufino JD, Castano N, Pang M, Grody EI, Joubran S, Caulier A, Wahlster L, Li T, Qiu X, Riera-Escandell AM, Newby GA, Al'Khafaji A, Chaudhary S, Black S, Weng C, Munson G, Liu DR, Wlodarski MW, Sims K, Oakley JH...
Deep proteomics identifies shared molecular pathway alterations in synapses of patients with schizophrenia and bipolar disorder and mouse model.
Aryal, Sameer, Kevin Bonanno, Bryan Song, D R Mani, Hasmik Keshishian, Steven A Carr, Morgan Sheng, and Borislav Dejanovic. 2023. “Deep Proteomics Identifies Shared Molecular Pathway Alterations in Synapses of Patients With Schizophrenia and Bipolar Disorder and Mouse Model.”. Cell Reports 42 (5): 112497.
Opportunities
We are currently looking for doctoral students. Prospective students should be enrolled in a qualifying Ph.D. or M.D./Ph.D. program at Harvard in order to join the lab. No specific background is required. If you are interested, please reach out to Luke with your C.V. If you join the lab, possible...
A synaptic molecular dependency network in knockdown of autism- and schizophrenia-associated genes revealed by multiplexed imaging.
Falkovich, Reuven, Eric W Danielson, Karen Perez de Arce, Eike-C Wamhoff, Juliana Strother, Anna P Lapteva, Morgan Sheng, Jeffrey R Cottrell, and Mark Bathe. 2023. “A Synaptic Molecular Dependency Network in Knockdown of Autism- and Schizophrenia-Associated Genes Revealed by Multiplexed Imaging.”. Cell Reports 42 (5): 112430.
Which single cell technology is best?
Jason, Luca and others weigh on on which single cell technology is best (for which application...?) in a Nature Technology Feature: https://www.nature.com/articles/d41586-022-04426-5
Best Practices for Jupyter Notebook
When you are new to the coding world, a lot of new information can be overwhelming. Staying organized might help ease the learning process. This blog post is about simple ways to organize your Jupyter notebooks to make them more reproducible and user-friendly. First, let me begin by introducing the...
Microscopy in the cloud: CellProfiler and Cell Painting on Terra
Microscopy in the cloud: CellProfiler and Cell Painting on Terra Authors: Carmen Diaz Verdugo, Stephen Fleming, Nicole Deflaux and Amy Unruh Carmen Diaz Verdugo is a Computational Scientist in the Precision Cardiology Lab, and a member of Patrick Ellinor’s group. Stephen Fleming is a Senior Machine...
Heejo Choi
I am a computational biologist interested in the integration, interpretation, and visualization of data elucidating cancer dependencies in the context of the tumor microenvironment.