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Zixin Chen

Person: Graduate Student, Broad Institute

Zixin Chen, MD Zixin is a PhD student specializing in pancreatic surgery at West China Hospital of Sichuan University. Since October 2023, he joined the Raghavan Lab as a visiting graduate student. Zixin is interested in understanding the heterogeneity and molecular subtype plasticity of pancreatic...

CD300LF Polymorphisms of Inbred Mouse Strains Confer Resistance to Murine Norovirus Infection in a Cell Type-Dependent Manner.

Publication: Journal Article

Furlong, Kevin, Scott B Biering, Jayoung Choi, Craig B Wilen, Robert C Orchard, Christiane E Wobus, Christopher A Nelson, et al. 2020. “CD300LF Polymorphisms of Inbred Mouse Strains Confer Resistance to Murine Norovirus Infection in a Cell Type-Dependent Manner.”. Journal of Virology 94 (17).

Murine Norovirus Infection Induces TH1 Inflammatory Responses to Dietary Antigens.

Publication: Journal Article

Bouziat, Romain, Scott B Biering, Elaine Kouame, Kishan A Sangani, Soowon Kang, Jordan D Ernest, Mukund Varma, et al. 2018. “Murine Norovirus Infection Induces TH1 Inflammatory Responses to Dietary Antigens.”. Cell Host & Microbe 24 (5): 677-688.e5.

LysMD3 is a type II membrane protein without an in vivo role in the response to a range of pathogens.

Publication: Journal Article

Yokoyama, Christine C, Megan T Baldridge, Daisy W Leung, Guoyan Zhao, Chandni Desai, Ta-Chiang Liu, Vladimir E Diaz-Ochoa, et al. 2018. “LysMD3 Is a Type II Membrane Protein Without an in Vivo Role in the Response to a Range of Pathogens.”. The Journal of Biological Chemistry 293 (16): 6022-38.

Quo vadis? Interferon-inducible GTPases go to their target membranes via the LC3-conjugation system of autophagy.

Publication: Journal Article

Choi, Jayoung, Scott B Biering, and Seungmin Hwang. 2017. “Quo Vadis? Interferon-Inducible GTPases Go to Their Target Membranes via the LC3-Conjugation System of Autophagy.”. Small GTPases 8 (4): 199-207.

Targeting by AutophaGy proteins (TAG): Targeting of IFNG-inducible GTPases to membranes by the LC3 conjugation system of autophagy.

Publication: Journal Article

Park, Sungwoo, Jayoung Choi, Scott B Biering, Erin Dominici, Lelia E Williams, and Seungmin Hwang. 2016. “Targeting by AutophaGy Proteins (TAG): Targeting of IFNG-Inducible GTPases to Membranes by the LC3 Conjugation System of Autophagy.”. Autophagy 12 (7): 1153-67.

Gamma-herpesvirus kinase actively initiates a DNA damage response by inducing phosphorylation of H2AX to foster viral replication.

Publication: Journal Article

Tarakanova, Vera L, Van Leung-Pineda, Seungmin Hwang, Chiao-Wen Yang, Katie Matatall, Mickael Basson, Ren Sun, Helen Piwnica-Worms, Barry P Sleckman, and Herbert W Virgin. 2007. “Gamma-Herpesvirus Kinase Actively Initiates a DNA Damage Response by Inducing Phosphorylation of H2AX to Foster Viral Replication.”. Cell Host & Microbe 1 (4): 275-86.

The K-bZIP protein from Kaposi's sarcoma-associated herpesvirus interacts with p53 and represses its transcriptional activity.

Publication: Journal Article

Park, J, T Seo, S Hwang, D Lee, Y Gwack, and J Choe. 2000. “The K-BZIP Protein from Kaposi’s Sarcoma-Associated Herpesvirus Interacts With P53 and Represses Its Transcriptional Activity.”. Journal of Virology 74 (24): 11977-82.

Selective subversion of autophagy complexes facilitates completion of the Brucella intracellular cycle.

Publication: Journal Article

Starr, Tregei, Robert Child, Tara D Wehrly, Bryan Hansen, Seungmin Hwang, Carlos López-Otín, Herbert W Virgin, and Jean Celli. 2012. “Selective Subversion of Autophagy Complexes Facilitates Completion of the Brucella Intracellular Cycle.”. Cell Host & Microbe 11 (1): 33-45.

Viral Bcl-2-mediated evasion of autophagy aids chronic infection of gammaherpesvirus 68.

Publication: Journal Article

E, Xiaofei, Seungmin Hwang, Soohwan Oh, Jong-Soo Lee, Joseph H Jeong, Yousang Gwack, Timothy F Kowalik, Ren Sun, Jae U Jung, and Chengyu Liang. 2009. “Viral Bcl-2-Mediated Evasion of Autophagy Aids Chronic Infection of Gammaherpesvirus 68.”. PLoS Pathogens 5 (10): e1000609.