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Quo vadis? Interferon-inducible GTPases go to their target membranes via the LC3-conjugation system of autophagy.

Publication: Journal Article

Choi, Jayoung, Scott B Biering, and Seungmin Hwang. 2017. “Quo Vadis? Interferon-Inducible GTPases Go to Their Target Membranes via the LC3-Conjugation System of Autophagy.”. Small GTPases 8 (4): 199-207.

Targeting by AutophaGy proteins (TAG): Targeting of IFNG-inducible GTPases to membranes by the LC3 conjugation system of autophagy.

Publication: Journal Article

Park, Sungwoo, Jayoung Choi, Scott B Biering, Erin Dominici, Lelia E Williams, and Seungmin Hwang. 2016. “Targeting by AutophaGy Proteins (TAG): Targeting of IFNG-Inducible GTPases to Membranes by the LC3 Conjugation System of Autophagy.”. Autophagy 12 (7): 1153-67.

Gamma-herpesvirus kinase actively initiates a DNA damage response by inducing phosphorylation of H2AX to foster viral replication.

Publication: Journal Article

Tarakanova, Vera L, Van Leung-Pineda, Seungmin Hwang, Chiao-Wen Yang, Katie Matatall, Mickael Basson, Ren Sun, Helen Piwnica-Worms, Barry P Sleckman, and Herbert W Virgin. 2007. “Gamma-Herpesvirus Kinase Actively Initiates a DNA Damage Response by Inducing Phosphorylation of H2AX to Foster Viral Replication.”. Cell Host & Microbe 1 (4): 275-86.

The K-bZIP protein from Kaposi's sarcoma-associated herpesvirus interacts with p53 and represses its transcriptional activity.

Publication: Journal Article

Park, J, T Seo, S Hwang, D Lee, Y Gwack, and J Choe. 2000. “The K-BZIP Protein from Kaposi’s Sarcoma-Associated Herpesvirus Interacts With P53 and Represses Its Transcriptional Activity.”. Journal of Virology 74 (24): 11977-82.

Selective subversion of autophagy complexes facilitates completion of the Brucella intracellular cycle.

Publication: Journal Article

Starr, Tregei, Robert Child, Tara D Wehrly, Bryan Hansen, Seungmin Hwang, Carlos López-Otín, Herbert W Virgin, and Jean Celli. 2012. “Selective Subversion of Autophagy Complexes Facilitates Completion of the Brucella Intracellular Cycle.”. Cell Host & Microbe 11 (1): 33-45.

Viral Bcl-2-mediated evasion of autophagy aids chronic infection of gammaherpesvirus 68.

Publication: Journal Article

E, Xiaofei, Seungmin Hwang, Soohwan Oh, Jong-Soo Lee, Joseph H Jeong, Yousang Gwack, Timothy F Kowalik, Ren Sun, Jae U Jung, and Chengyu Liang. 2009. “Viral Bcl-2-Mediated Evasion of Autophagy Aids Chronic Infection of Gammaherpesvirus 68.”. PLoS Pathogens 5 (10): e1000609.

Kaposi's sarcoma-associated herpesvirus K8 protein interacts with hSNF5.

Publication: Journal Article

Hwang, Seungmin, Daeyoup Lee, Yousang Gwack, Hyesun Min, and Joonho Choe. 2003. “Kaposi’s Sarcoma-Associated Herpesvirus K8 Protein Interacts With HSNF5.”. The Journal of General Virology 84 (Pt 3): 665-76.

The dual function monoclonal antibodies VIR-7831 and VIR-7832 demonstrate potent in vitro and in vivo activity against SARS-CoV-2

Publication: Journal Article

Cathcart, Andrea L., Colin Havenar-Daughton, Florian A. Lempp, Daphne Ma, Michael A. Schmid, Maria L. Agostini, Barbara Guarino, et al. 2022. “The Dual Function Monoclonal Antibodies VIR-7831 and VIR-7832 Demonstrate Potent in Vitro and in Vivo Activity Against SARS-CoV-2”. BioRxiv.

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News: July 21, 2022

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Sebastiano Cultrera di Montesano

Person: Postdoctoral Associate, Broad Institute

Sebastiano Cultrera di Montesano, PhD Sebastiano is a postdoctoral fellow at the EWSC , a center bridging AI and biology at the Broad Institute of MIT and Harvard. He obtained his PhD in computational topology at the Institute of Science and Technology Austria , working under the supervision of Prof...