PDZ domains: structural modules for protein complex assembly.
Hung, Albert Y, and Morgan Sheng. 2002. “PDZ Domains: Structural Modules for Protein Complex Assembly.”. The Journal of Biological Chemistry 277 (8): 5699-702.
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TREM2-dependent microglial function is essential for remyelination and subsequent neuroprotection.
Wang, Yuanyuan, Roxanne Kyauk V, Yun-An A Shen, Luke Xie, Mike Reichelt, Han Lin, Zhiyu Jiang, et al. 2023. “TREM2-Dependent Microglial Function Is Essential for Remyelination and Subsequent Neuroprotection.”. Glia 71 (5): 1247-58.
GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer's Disease Models.
Hanson, Jesse E, Keran Ma, Justin Elstrott, Martin Weber, Sandrine Saillet, Abdullah S Khan, Jeffrey Simms, et al. 2020. “GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer’s Disease Models.”. Cell Reports 30 (2): 381-396.e4.
Microglia in Brain Development, Homeostasis, and Neurodegeneration.
Bohlen, Christopher J, Brad A Friedman, Borislav Dejanovic, and Morgan Sheng. 2019. “Microglia in Brain Development, Homeostasis, and Neurodegeneration.”. Annual Review of Genetics 53: 263-88.
Progranulin deficiency causes impairment of autophagy and TDP-43 accumulation.
Chang, Michael C, Karpagam Srinivasan, Brad A Friedman, Eric Suto, Zora Modrusan, Wyne P Lee, Joshua S Kaminker, David Hansen V, and Morgan Sheng. 2017. “Progranulin Deficiency Causes Impairment of Autophagy and TDP-43 Accumulation.”. The Journal of Experimental Medicine 214 (9): 2611-28.
TREM2, Microglia, and Neurodegenerative Diseases.
Yeh, Felix L, David Hansen V, and Morgan Sheng. 2017. “TREM2, Microglia, and Neurodegenerative Diseases.”. Trends in Molecular Medicine 23 (6): 512-33.
The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy.
Bingol, Baris, Joy S Tea, Lilian Phu, Mike Reichelt, Corey E Bakalarski, Qinghua Song, Oded Foreman, Donald S Kirkpatrick, and Morgan Sheng. 2014. “The Mitochondrial Deubiquitinase USP30 Opposes Parkin-Mediated Mitophagy.”. Nature 510 (7505): 370-5.
NMDA receptors in nervous system diseases.
Zhou, Qiang, and Morgan Sheng. 2013. “NMDA Receptors in Nervous System Diseases.”. Neuropharmacology 74: 69-75.
Specific trans-synaptic interaction with inhibitory interneuronal neurexin underlies differential ability of neuroligins to induce functional inhibitory synapses.
Futai, Kensuke, Christopher D Doty, Brian Baek, Jubin Ryu, and Morgan Sheng. 2013. “Specific Trans-Synaptic Interaction With Inhibitory Interneuronal Neurexin Underlies Differential Ability of Neuroligins to Induce Functional Inhibitory Synapses.”. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience 33 (8): 3612-23.
GKAP orchestrates activity-dependent postsynaptic protein remodeling and homeostatic scaling.
Shin, Seung Min, Nanyan Zhang, Jonathan Hansen, Nashaat Z Gerges, Daniel T S Pak, Morgan Sheng, and Sang H Lee. 2012. “GKAP Orchestrates Activity-Dependent Postsynaptic Protein Remodeling and Homeostatic Scaling.”. Nature Neuroscience 15 (12): 1655-66.