Fadi J Najm, Ph.D., MBA
Principal Investigator, Broad Institute
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Luca Pinello, Ph.D.
Principal Investigator, Molecular Pathology Unit, Mass General Research Institute Associate Professor of Pathology, Harvard Medical School
Eric S. Lander, Ph.D.
Core Institute Member & Founding Director, Broad Institute Professor, Department of Biology, MIT Professor of Systems Biology, Harvard Medical School
Eugenio Mattei, Ph.D.
Senior Computational Scientist I GRO, Broad Institute
Nina Farrell, MPS, PMP
Project Manager II
Brady Walker
Project Coordinator, GRO and dGTEx
Base editor scanning charts the DNMT3A activity landscape.
Lue, Nicholas Z, Emma M Garcia, Kevin C Ngan, Ceejay Lee, John G Doench, and Brian B Liau. 2023. “Base Editor Scanning Charts the DNMT3A Activity Landscape.”. Nature Chemical Biology 19 (2): 176-86.
CRISPR-suppressor scanning reveals a nonenzymatic role of LSD1 in AML.
Vinyard, Michael E, Cindy Su, Allison P Siegenfeld, Amanda L Waterbury, Allyson M Freedy, Pallavi M Gosavi, Yongho Park, et al. 2019. “CRISPR-Suppressor Scanning Reveals a Nonenzymatic Role of LSD1 in AML.”. Nature Chemical Biology 15 (5): 529-39.
GRAFIMO: Variant and haplotype aware motif scanning on pangenome graphs.
Tognon, Manuel, Vincenzo Bonnici, Erik Garrison, Rosalba Giugno, and Luca Pinello. 2021. “GRAFIMO: Variant and Haplotype Aware Motif Scanning on Pangenome Graphs.”. PLoS Computational Biology 17 (9): e1009444.
Screening thousands of transcribed coding and non-coding regions reveals sequence determinants of RNA polymerase II elongation potential.
Vlaming, Hanneke, Claudia A Mimoso, Andrew R Field, Benjamin J E Martin, and Karen Adelman. 2022. “Screening Thousands of Transcribed Coding and Non-Coding Regions Reveals Sequence Determinants of RNA Polymerase II Elongation Potential.”. Nature Structural & Molecular Biology 29 (6): 613-20.