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Seungmin "Sam" Hwang Principal Investigator Karen Zhu Senior Research Scientist Suji Kim Postdoctoral Associate Danny Papini Research Scientist Chukwudumebi "Dumebi" Okonkwo Research Associate Kyoungwha "Ellen" Pang Visiting Scholar Xiaoyu "Alina" Yang Postdoctoral Associate

Brook Heathcote

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The parasitophorous vacuole membrane of Toxoplasma gondii is targeted for disruption by ubiquitin-like conjugation systems of autophagy.

Publication: Journal Article

Choi, Jayoung, Sunmin Park, Scott B Biering, Elizabeth Selleck, Catherine Y Liu, Xin Zhang, Naonobu Fujita, et al. 2014. “The Parasitophorous Vacuole Membrane of Toxoplasma Gondii Is Targeted for Disruption by Ubiquitin-Like Conjugation Systems of Autophagy.”. Immunity 40 (6): 924-35.

Conserved herpesviral kinase promotes viral persistence by inhibiting the IRF-3-mediated type I interferon response.

Publication: Journal Article

Hwang, Seungmin, Kyeong Seon Kim, Emilio Flano, Ting-Ting Wu, Leming M Tong, Ann N Park, Moon Jung Song, et al. 2009. “Conserved Herpesviral Kinase Promotes Viral Persistence by Inhibiting the IRF-3-Mediated Type I Interferon Response.”. Cell Host & Microbe 5 (2): 166-78.

Persistent gammaherpesvirus replication and dynamic interaction with the host in vivo.

Publication: Journal Article

Hwang, Seungmin, Ting-Ting Wu, Leming M Tong, Kyeong Seon Kim, DeeAnn Martinez-Guzman, Arnaud D Colantonio, Christel H Uittenbogaart, and Ren Sun. 2008. “Persistent Gammaherpesvirus Replication and Dynamic Interaction With the Host in Vivo.”. Journal of Virology 82 (24): 12498-509.

CREB-binding protein and histone deacetylase regulate the transcriptional activity of Kaposi's sarcoma-associated herpesvirus open reading frame 50.

Publication: Journal Article

Gwack, Y, H Byun, S Hwang, C Lim, and J Choe. 2001. “CREB-Binding Protein and Histone Deacetylase Regulate the Transcriptional Activity of Kaposi’s Sarcoma-Associated Herpesvirus Open Reading Frame 50.”. Journal of Virology 75 (4): 1909-17.

The anti-interferon activity of conserved viral dUTPase ORF54 is essential for an effective MHV-68 infection.

Publication: Journal Article

Leang, Ronika Sitapara, Ting-Ting Wu, Seungmin Hwang, Lidia T Liang, Leming Tong, Jennifer T Truong, and Ren Sun. 2011. “The Anti-Interferon Activity of Conserved Viral DUTPase ORF54 Is Essential for an Effective MHV-68 Infection.”. PLoS Pathogens 7 (10): e1002292.

Kaposi's Sarcoma-associated herpesvirus open reading frame 50 stimulates the transcriptional activity of STAT3.

Publication: Journal Article

Gwack, Yousang, Seungmin Hwang, Chunghun Lim, Young Suk Won, Chul Ho Lee, and Joonho Choe. 2002. “Kaposi’s Sarcoma-Associated Herpesvirus Open Reading Frame 50 Stimulates the Transcriptional Activity of STAT3.”. The Journal of Biological Chemistry 277 (8): 6438-42.

Antibody-fused interferons as an effective approach to enhance target specificity and antiviral efficacy of type I interferons.

Publication: Journal Article

Cheng, Lucy S, Seungmin Hwang, Tzu-Hsuan Huang, Ting-Chang Sheu, Ren Sun, Sherie L Morrison, Genhong Cheng, and Arash Shahangian. 2008. “Antibody-Fused Interferons As an Effective Approach to Enhance Target Specificity and Antiviral Efficacy of Type I Interferons.”. Cell Research 18 (12): 1230-2.