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Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling

Publication: Journal Article

Wawer, M. J., K. Li, S. M. Gustafsdottir, V. Ljosa, N. E. Bodycombe, M. A. Marton, K. L. Sokolnicki, et al. 2014. “Toward Performance-Diverse Small-Molecule Libraries for Cell-Based Phenotypic Screening Using Multiplexed High-Dimensional Profiling”. Proc Natl Acad Sci U S A 111: 10911-6.

Three-dimensional Chromatin Landscapes in T cell Acute Lymphoblastic Leukemia

Publication: Journal Article

Kloetgen, Andreas, Palaniraja Thandapani, Panagiotis Ntziachristos, Yohana Ghebrechristos, Sofia Nomikou, Charalampos Lazaris, Xufeng Chen, et al. 2020. “Three-Dimensional Chromatin Landscapes in T Cell Acute Lymphoblastic Leukemia”. Nat Genet 52: 388-400.

cmg

Human U2OS Cells – profiling bioactive compounds using Cell Painting

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Accession number BBBC036 · Version 1 Example images Description of the biological application Phenotypic profiling attempts to summarize multiparametric, feature-based analysis of cellular phenotypes of each sample so that similarities between profiles reflect similarities between samples. This...

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Impact on Human Health

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Our CellProfiler software has yielded discoveries in several translational projects, some of which have had a direct impact on the treatment of disease. For example, CellProfiler has been used to identify several small molecules that are effective in treating particular diseases in mouse models. In...

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Activities

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Meetings Meetings may be conducted in person or by conference call. The Center Chair will notify all members of the place, day, time and purpose for any meeting. Public Q&A Sessions These sessions are open to the public and we encourage school faculty and students to attend. The purpose of these...

Laura De Santos

Person: Project Director

Laura De Santos is a project director at the Center for Financial Aid Policy Research and oversees the center's projects. Previously, she was the research manager for the National Center for Student Readiness. Laura holds a M.A. in educational management from Joseph Thomas College. She is a former...