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585 results found

High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines

Publication: Journal Article

Yu, C., A. M. Mannan, G. M. Yvone, K. N. Ross, Y. L. Zhang, M. A. Marton, B. R. Taylor, et al. 2016. “High-Throughput Identification of Genotype-Specific Cancer Vulnerabilities in Mixtures of Barcoded Tumor Cell Lines”. Nat Biotechnol 34: 419-23.

Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers

Publication: Journal Article

Parikh, A. R., I. Leshchiner, L. Elagina, L. Goyal, C. Levovitz, G. Siravegna, D. Livitz, et al. 2019. “Liquid versus Tissue Biopsy for Detecting Acquired Resistance and Tumor Heterogeneity in Gastrointestinal Cancers”. Nat Med 25: 1415-21.

A method for high-throughput gene expression signature analysis

Publication: Journal Article

Peck, D., E. D. Crawford, K. N. Ross, K. Stegmaier, T. R. Golub, and J. Lamb. 2006. “A Method for High-Throughput Gene Expression Signature Analysis”. Genome Biol 7: R61.

MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia

Publication: Journal Article

Pikman, Y., B. H. Lee, T. Mercher, E. McDowell, B. L. Ebert, M. Gozo, A. Cuker, et al. 2006. “MPLW515L Is a Novel Somatic Activating Mutation in Myelofibrosis With Myeloid Metaplasia”. PLoS Med 3: e270.

Retraction Note: Selective killing of cancer cells by a small molecule targeting the stress response to ROS

Publication: Journal Article

Raj, L., T. Ide, A. U. Gurkar, M. Foley, M. Schenone, X. Li, N. J. Tolliday, et al. 2018. “Retraction Note: Selective Killing of Cancer Cells by a Small Molecule Targeting the Stress Response to ROS”. Nature 561: 420.

Multiclass cancer diagnosis using tumor gene expression signatures

Publication: Journal Article

Ramaswamy, S., P. Tamayo, R. Rifkin, S. Mukherjee, C. H. Yeang, M. Angelo, C. Ladd, et al. 2001. “Multiclass Cancer Diagnosis Using Tumor Gene Expression Signatures”. Proc Natl Acad Sci U S A 98: 15149-54.

The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K

Publication: Journal Article

Slabicki, M., Z. Kozicka, G. Petzold, Y. D. Li, M. Manojkumar, R. D. Bunker, K. A. Donovan, et al. 2020. “The CDK Inhibitor CR8 Acts As a Molecular Glue Degrader That Depletes Cyclin K”. Nature 585: 293-97.

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CellProfiler is free, open-source software for quantitative analysis of biological images. No prior experience in programming or computer vision is required – this page is intended to help you get up and running. The quickest way to get up and running with CellProfiler is to: Download CellProfiler...

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COBA periodically reviews project proposals from the community, seeking driving biological projects related to the technological advancements in progress for a long-term (many months) collaborations. Principal Investigators with laboratories in the United States are welcome to describe a potential...