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607 results found

Chemical genomics identifies small-molecule MCL1 repressors and BCL-xL as a predictor of MCL1 dependency

Publication: Journal Article

Wei, G., A. A. Margolin, L. Haery, E. Brown, L. Cucolo, B. Julian, S. Shehata, A. L. Kung, R. Beroukhim, and T. R. Golub. 2012. “Chemical Genomics Identifies Small-Molecule MCL1 Repressors and BCL-XL As a Predictor of MCL1 Dependency”. Cancer Cell 21: 547-62.

Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance

Publication: Journal Article

Wei, G., D. Twomey, J. Lamb, K. Schlis, J. Agarwal, R. W. Stam, J. T. Opferman, et al. 2006. “Gene Expression-Based Chemical Genomics Identifies Rapamycin As a Modulator of MCL1 and Glucocorticoid Resistance”. Cancer Cell 10: 331-42.

High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines

Publication: Journal Article

Yu, C., A. M. Mannan, G. M. Yvone, K. N. Ross, Y. L. Zhang, M. A. Marton, B. R. Taylor, et al. 2016. “High-Throughput Identification of Genotype-Specific Cancer Vulnerabilities in Mixtures of Barcoded Tumor Cell Lines”. Nat Biotechnol 34: 419-23.

Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers

Publication: Journal Article

Parikh, A. R., I. Leshchiner, L. Elagina, L. Goyal, C. Levovitz, G. Siravegna, D. Livitz, et al. 2019. “Liquid versus Tissue Biopsy for Detecting Acquired Resistance and Tumor Heterogeneity in Gastrointestinal Cancers”. Nat Med 25: 1415-21.

A method for high-throughput gene expression signature analysis

Publication: Journal Article

Peck, D., E. D. Crawford, K. N. Ross, K. Stegmaier, T. R. Golub, and J. Lamb. 2006. “A Method for High-Throughput Gene Expression Signature Analysis”. Genome Biol 7: R61.

MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia

Publication: Journal Article

Pikman, Y., B. H. Lee, T. Mercher, E. McDowell, B. L. Ebert, M. Gozo, A. Cuker, et al. 2006. “MPLW515L Is a Novel Somatic Activating Mutation in Myelofibrosis With Myeloid Metaplasia”. PLoS Med 3: e270.

Retraction Note: Selective killing of cancer cells by a small molecule targeting the stress response to ROS

Publication: Journal Article

Raj, L., T. Ide, A. U. Gurkar, M. Foley, M. Schenone, X. Li, N. J. Tolliday, et al. 2018. “Retraction Note: Selective Killing of Cancer Cells by a Small Molecule Targeting the Stress Response to ROS”. Nature 561: 420.

Multiclass cancer diagnosis using tumor gene expression signatures

Publication: Journal Article

Ramaswamy, S., P. Tamayo, R. Rifkin, S. Mukherjee, C. H. Yeang, M. Angelo, C. Ladd, et al. 2001. “Multiclass Cancer Diagnosis Using Tumor Gene Expression Signatures”. Proc Natl Acad Sci U S A 98: 15149-54.

The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K

Publication: Journal Article

Slabicki, M., Z. Kozicka, G. Petzold, Y. D. Li, M. Manojkumar, R. D. Bunker, K. A. Donovan, et al. 2020. “The CDK Inhibitor CR8 Acts As a Molecular Glue Degrader That Depletes Cyclin K”. Nature 585: 293-97.

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