Themes
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Broad Global Health Initiative
CellProfiler Analyst
Official website for open source software CellProfiler Analyst
Publications
Selected publications and preprints Nadig, A., Replogle, J. M., Pogson, A. N., McCarroll, S. A., Weissman, J. S., Robinson, E. B., & O'Connor, L. J. (2024). Transcriptome-wide characterization of genetic perturbations. bioRxiv, 2024-07. Salehi Nowbandegai, P.*, Wohns, A. W.*, …, Neale, B. M. & O...
Pan Group
The Pan Group in the Stanley Center for Psychiatric Research focuses on translating emerging human genetics into biological insights that can be turned into potential novel therapeutics for major psychiatric illnesses including schizophrenia and bipolar disorders.
Selective modulation of a pan-essential protein as a therapeutic strategy in cancer
Malone, Clare F., Neekesh V. Dharia, Guillaume Kugener, Alexandra B. Forman, Michael V. Rothberg, Mai Abdusamad, Alfredo Gonzalez, et al. 2021. “Selective Modulation of a Pan-Essential Protein As a Therapeutic Strategy in Cancer”. Cancer Discov.
Different roles of T-type calcium channel isoforms in hypnosis induced by an endogenous neurosteroid epipregnanolone
Coulter, Ian, Tamara Timic Stamenic, Pierce Eggan, Brier R Fine, Timothy Corrigan, Douglas F Covey, Lingling Yang, Jen Q Pan, and Slobodan M Todorovic. 2021. “Different Roles of T-Type Calcium Channel Isoforms in Hypnosis Induced by an Endogenous Neurosteroid Epipregnanolone”. Neuropharmacology.
Duplex-Repair enables highly accurate sequencing, despite DNA damage
Xiong, Kan, Douglas Shea, Justin Rhoades, Timothy Blewett, Ruolin Liu, Jin H Bae, Erica Nguyen, Mike Makrigiorgos, Todd R Golub, and Viktor A Adalsteinsson. 2021. “Duplex-Repair Enables Highly Accurate Sequencing, Despite DNA Damage”. Nucleic Acids Res 50 (1).
Noncanonical open reading frames encode functional proteins essential for cancer cell survival
Prensner, JR, OM Enache, Luria, Krug, KR Clauser, JM Dempster, Karger, et al. 2021. “Noncanonical Open Reading Frames Encode Functional Proteins Essential for Cancer Cell Survival”. Nature Biotechnology.