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197 results found

Clathrin adaptor AP2 and NSF interact with overlapping sites of GluR2 and play distinct roles in AMPA receptor trafficking and hippocampal LTD.

Publication: Journal Article

Lee, Sang Hyoung, Lidong Liu, Yu Tian Wang, and Morgan Sheng. 2002. “Clathrin Adaptor AP2 and NSF Interact With Overlapping Sites of GluR2 and Play Distinct Roles in AMPA Receptor Trafficking and Hippocampal LTD.”. Neuron 36 (4): 661-74.

Neurobiology: glutamate receptors on the move.

Publication: Journal Article

Sheng, Morgan, and Terunaga Nakagawa. 2002. “Neurobiology: Glutamate Receptors on the Move.”. Nature 417 (6889): 601-2.

Postsynaptic calcium signaling microdomains in neurons.

Publication: Journal Article

Blackstone, Craig, and Morgan Sheng. 2002. “Postsynaptic Calcium Signaling Microdomains in Neurons.”. Frontiers in Bioscience : A Journal and Virtual Library 7: d872-85.

Prabhat Kunwar, Ph.D.

he/him

Person: Senior Group Leader

Prabhat Kunwar is a senior group leader in the Stanley Center for Psychiatric Research at the Broad Institute of MIT and Harvard. His research focuses on understanding the neural circuit mechanisms underlying mental illnesses and translating those discoveries into novel therapeutics. His team’s...

Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model.

Publication: Journal Article

Meilandt, William J, Hai Ngu, Alvin Gogineni, Guita Lalehzadeh, Seung-Hye Lee, Karpagam Srinivasan, Jose Imperio, et al. 2020. “Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer’s Mouse Model.”. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience 40 (9): 1956-74.

SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse.

Publication: Journal Article

Koopmans, Frank, Pim van Nierop, Maria Andres-Alonso, Andrea Byrnes, Tony Cijsouw, Marcelo P Coba, Niels Cornelisse, et al. 2019. “SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse.”. Neuron 103 (2): 217-234.e4.

PTCD1 Is Required for Mitochondrial Oxidative-Phosphorylation: Possible Genetic Association with Alzheimer's Disease.

Publication: Journal Article

Fleck, Daniel, Lilian Phu, Erik Verschueren, Trent Hinkle, Mike Reichelt, Tushar Bhangale, Benjamin Haley, et al. 2019. “PTCD1 Is Required for Mitochondrial Oxidative-Phosphorylation: Possible Genetic Association With Alzheimer’s Disease.”. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience 39 (24): 4636-56.

TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia.

Publication: Journal Article

Yeh, Felix L, Yuanyuan Wang, Irene Tom, Lino C Gonzalez, and Morgan Sheng. 2016. “TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia.”. Neuron 91 (2): 328-40.

Mechanisms of mitophagy: PINK1, Parkin, USP30 and beyond.

Publication: Journal Article

Bingol, Baris, and Morgan Sheng. 2016. “Mechanisms of Mitophagy: PINK1, Parkin, USP30 and Beyond.”. Free Radical Biology & Medicine 100: 210-22.

A Septin-Dependent Diffusion Barrier at Dendritic Spine Necks.

Publication: Journal Article

Ewers, Helge, Tomoko Tada, Jennifer D Petersen, Bence Racz, Morgan Sheng, and Daniel Choquet. 2014. “A Septin-Dependent Diffusion Barrier at Dendritic Spine Necks.”. PloS One 9 (12): e113916.