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Qui ut voluptatem voluptatem velit molestias hic ad nihil nostrum.Quis nihil ea veniam labore ducimus velit eos. Natus Eos Sed Maiores In Neque Dolores Et. Minima praesentium repudiandae sed nam qui iusto nulla occaecati tempore. Eos sunt ut repudiandae distinctio. Aspernatur cumque quos ab pariatur...

Melina Claussnitzer, PhD

Person:

Associate Director of Scientific Strategy, Novo Nordisk Foundation Center, Broad Institute Co-Director, Type 2 Diabetes Systems Genomics Initiative, Broad Institute Assistant Professor, Harvard Medical School & Beth Israel Deaconess Medical Center Investigator, Center for Genomic Medicine and...

The neuronal pentraxin Nptx2 regulates complement activity and restrains microglia-mediated synapse loss in neurodegeneration.

Publication: Journal Article

Zhou, Jiechao, Sarah D Wade, David Graykowski, Mei-Fang Xiao, Binhui Zhao, Lucia A A Giannini, Jesse E Hanson, et al. 2023. “The Neuronal Pentraxin Nptx2 Regulates Complement Activity and Restrains Microglia-Mediated Synapse Loss in Neurodegeneration.”. Science Translational Medicine 15 (689): eadf0141.

Regulation of purine metabolism connects KCTD13 to a metabolic disorder with autistic features.

Publication: Journal Article

Madison, Jon M, Karen Duong, Ellen F Vieux, Namrata D Udeshi, Sumaiya Iqbal, Elise Requadt, Shaunt Fereshetian, et al. 2021. “Regulation of Purine Metabolism Connects KCTD13 to a Metabolic Disorder With Autistic Features.”. IScience 24 (1): 101935.

PCDH7 interacts with GluN1 and regulates dendritic spine morphology and synaptic function.

Publication: Journal Article

Wang, Yuanyuan, Meghan Kerrisk Campbell, Irene Tom, Oded Foreman, Jesse E Hanson, and Morgan Sheng. 2020. “PCDH7 Interacts With GluN1 and Regulates Dendritic Spine Morphology and Synaptic Function.”. Scientific Reports 10 (1): 10951.

Degradation of postsynaptic scaffold GKAP and regulation of dendritic spine morphology by the TRIM3 ubiquitin ligase in rat hippocampal neurons.

Publication: Journal Article

Hung, Albert Y, Clifford C Sung, Ilana L Brito, and Morgan Sheng. 2010. “Degradation of Postsynaptic Scaffold GKAP and Regulation of Dendritic Spine Morphology by the TRIM3 Ubiquitin Ligase in Rat Hippocampal Neurons.”. PloS One 5 (3): e9842.

Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132.

Publication: Journal Article

Edbauer, Dieter, Joel R Neilson, Kelly A Foster, Chi-Fong Wang, Daniel P Seeburg, Matthew N Batterton, Tomoko Tada, Bridget M Dolan, Phillip A Sharp, and Morgan Sheng. 2010. “Regulation of Synaptic Structure and Function by FMRP-Associated MicroRNAs MiR-125b and MiR-132.”. Neuron 65 (3): 373-84.

The postsynaptic density.

Publication: Journal Article

Kim, Eunjoon, and Morgan Sheng. 2009. “The Postsynaptic Density.”. Current Biology : CB 19 (17): R723-4.

Trans-synaptic adhesion between NGL-3 and LAR regulates the formation of excitatory synapses.

Publication: Journal Article

Woo, Jooyeon, Seok-Kyu Kwon, Seungwon Choi, Seho Kim, Jae-Ran Lee, Anthone W Dunah, Morgan Sheng, and Eunjoon Kim. 2009. “Trans-Synaptic Adhesion Between NGL-3 and LAR Regulates the Formation of Excitatory Synapses.”. Nature Neuroscience 12 (4): 428-37.

Role of Septin cytoskeleton in spine morphogenesis and dendrite development in neurons.

Publication: Journal Article

Tada, Tomoko, Alyson Simonetta, Matthew Batterton, Makoto Kinoshita, Dieter Edbauer, and Morgan Sheng. 2007. “Role of Septin Cytoskeleton in Spine Morphogenesis and Dendrite Development in Neurons.”. Current Biology : CB 17 (20): 1752-8.