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News: July 21, 2022

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Andrew Navia

Person: Research Scientist, Broad Institute

Andrew Navia, PhD Andrew is interested in using single-cell techniques to study new RNA states in solid tumors. This builds on work completed during his PhD in the Shalek Lab at MIT. In his free time he enjoys hiking and running.

Tsukasa Shibue

Person: Senior Research Scientist, Broad Institute

Tsukasa Shibue, PhD Tsukasa is an expert of target(s). On weekdays, he works on validation projects of potential cancer therapeutic targets with a goal of saving patients' lives. On weekends, he goes to Target to buy goods that might save his own life.

The parasitophorous vacuole membrane of Toxoplasma gondii is targeted for disruption by ubiquitin-like conjugation systems of autophagy.

Publication: Journal Article

Choi, Jayoung, Sunmin Park, Scott B Biering, Elizabeth Selleck, Catherine Y Liu, Xin Zhang, Naonobu Fujita, et al. 2014. “The Parasitophorous Vacuole Membrane of Toxoplasma Gondii Is Targeted for Disruption by Ubiquitin-Like Conjugation Systems of Autophagy.”. Immunity 40 (6): 924-35.

Conserved herpesviral kinase promotes viral persistence by inhibiting the IRF-3-mediated type I interferon response.

Publication: Journal Article

Hwang, Seungmin, Kyeong Seon Kim, Emilio Flano, Ting-Ting Wu, Leming M Tong, Ann N Park, Moon Jung Song, et al. 2009. “Conserved Herpesviral Kinase Promotes Viral Persistence by Inhibiting the IRF-3-Mediated Type I Interferon Response.”. Cell Host & Microbe 5 (2): 166-78.

Persistent gammaherpesvirus replication and dynamic interaction with the host in vivo.

Publication: Journal Article

Hwang, Seungmin, Ting-Ting Wu, Leming M Tong, Kyeong Seon Kim, DeeAnn Martinez-Guzman, Arnaud D Colantonio, Christel H Uittenbogaart, and Ren Sun. 2008. “Persistent Gammaherpesvirus Replication and Dynamic Interaction With the Host in Vivo.”. Journal of Virology 82 (24): 12498-509.

CREB-binding protein and histone deacetylase regulate the transcriptional activity of Kaposi's sarcoma-associated herpesvirus open reading frame 50.

Publication: Journal Article

Gwack, Y, H Byun, S Hwang, C Lim, and J Choe. 2001. “CREB-Binding Protein and Histone Deacetylase Regulate the Transcriptional Activity of Kaposi’s Sarcoma-Associated Herpesvirus Open Reading Frame 50.”. Journal of Virology 75 (4): 1909-17.

The anti-interferon activity of conserved viral dUTPase ORF54 is essential for an effective MHV-68 infection.

Publication: Journal Article

Leang, Ronika Sitapara, Ting-Ting Wu, Seungmin Hwang, Lidia T Liang, Leming Tong, Jennifer T Truong, and Ren Sun. 2011. “The Anti-Interferon Activity of Conserved Viral DUTPase ORF54 Is Essential for an Effective MHV-68 Infection.”. PLoS Pathogens 7 (10): e1002292.

Kaposi's Sarcoma-associated herpesvirus open reading frame 50 stimulates the transcriptional activity of STAT3.

Publication: Journal Article

Gwack, Yousang, Seungmin Hwang, Chunghun Lim, Young Suk Won, Chul Ho Lee, and Joonho Choe. 2002. “Kaposi’s Sarcoma-Associated Herpesvirus Open Reading Frame 50 Stimulates the Transcriptional Activity of STAT3.”. The Journal of Biological Chemistry 277 (8): 6438-42.