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Safia Mohamed

Person: Broad 2025 BSSP

Safia joined BSSP drawn to the intersection of neuroscience, genetics, and mental health. At the Stanley Center, she studied the I900S variant of NR3C2, the gene encoding the mineralocorticoid receptor (MR), which regulates stress responses and is linked to schizophrenia risk.

AKT inhibition in the central nervous system induces signaling defects resulting in psychiatric symptomatology

Publication: Manuscript

Tsimberidou, Apostolia-Maria. 2022. “AKT Inhibition in the Central Nervous System Induces Signaling Defects Resulting in Psychiatric Symptomatology.”

Neurogranin, Encoded by the Schizophrenia Risk Gene NRGN, Bidirectionally Modulates Synaptic Plasticity via Calmodulin-Dependent Regulation of the Neuronal Phosphoproteome

Publication: Journal Article

Hwang, Hongik, Matthew J. Szucs, Lei J. Ding, Andrew Allen, Xiaobai Ren, Henny Haensgen, Fan Gao, et al. 2021. “Neurogranin, Encoded by the Schizophrenia Risk Gene NRGN, Bidirectionally Modulates Synaptic Plasticity via Calmodulin-Dependent Regulation of the Neuronal Phosphoproteome”. Biological Psychiatry 89 (3): 256-69.

Selective inhibition of glycogen synthase kinase 3α corrects pathophysiology in a mouse model of fragile X syndrome

Publication: Journal Article

McCamphill, Patrick, Laura Stoppel, Rebecca Senter, Michael Lewis, Arnold Heynen, David Stoppel, Vinay Sridhar, et al. 2020. “Selective Inhibition of Glycogen Synthase Kinase 3α Corrects Pathophysiology in a Mouse Model of Fragile X Syndrome”. Science Translational Medicine 12 (544).

Exploiting an Asp-Glu “switch” in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia

Publication: Journal Article

Wagner, Florence, Lina Benajiba, Arthur Campbell, Michel We{\"ıwer, Joshua Sacher, Jennifer Gale, Linda Ross, et al. 2018. “Exploiting an Asp-Glu ‘switch’ in Glycogen Synthase Kinase 3 to Design Paralog-Selective Inhibitors for Use in Acute Myeloid Leukemia”. Science Translational Medicine 10 (431).

Overexpression of NEUROG2 and NEUROG1 in human embryonic stem cells produces a network of excitatory and inhibitory neurons

Publication: Journal Article

Lu, Congyi, Xi Shi, Andrew Allen, David Baez-Nieto, Alexandria Nikish, Neville Sanjana, and Jen Pan. 2019. “Overexpression of NEUROG2 and NEUROG1 in Human Embryonic Stem Cells Produces a Network of Excitatory and Inhibitory Neurons”. The FASEB Journal 33 (4): 5287–5299.

Acoustic tweezers for the life sciences

Publication: Journal Article

Ozcelik, Adem, Joseph Rufo, Feng Guo, Yuyang Gu, Peng Li, James Lata, and Tony Jun Huang. 2018. “Acoustic Tweezers for the Life Sciences”. Nature Methods 15 (12): 1021–1028.

James Coleman, B.S.

Person: Research Associate I

Before graduating from Northeastern University in May 2020 with a BS in behavioral neuroscience, James was involved in research studying sleep, memory and pharmacology using both neuroimaging and electrophysiological approaches. His undergraduate thesis was on the neurological and behavioral effects...

Dara Manoach, Ph.D.

Person: Professor of Psychology at Department of Psychiatry at Harvard Medical School

Lei A Wang, Ph.D.

Person: Research Scientist I

Lei is an interdisciplinary scientist with skills in neuroscience, machine learning, and software development. He received his PhD in Pharmacodymamics (with a focus on Neuroscience) from University of Florida. He completed his postdoctoral training in neurophysiology at University of North Texas...