Constitutively active Rap2 transgenic mice display fewer dendritic spines, reduced extracellular signal-regulated kinase signaling, enhanced long-term depression, and impaired spatial learning and fear extinction.
Ryu, Jubin, Kensuke Futai, Monica Feliu, Richard Weinberg, and Morgan Sheng. 2008. “Constitutively Active Rap2 Transgenic Mice Display Fewer Dendritic Spines, Reduced Extracellular Signal-Regulated Kinase Signaling, Enhanced Long-Term Depression, and Impaired Spatial Learning and Fear Extinction.”. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience 28 (33): 8178-88.