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98 results found

CRISPR-suppressor scanning reveals a nonenzymatic role of LSD1 in AML.

Publication: Journal Article

Vinyard, Michael E, Cindy Su, Allison P Siegenfeld, Amanda L Waterbury, Allyson M Freedy, Pallavi M Gosavi, Yongho Park, et al. 2019. “CRISPR-Suppressor Scanning Reveals a Nonenzymatic Role of LSD1 in AML.”. Nature Chemical Biology 15 (5): 529-39.

GRAFIMO: Variant and haplotype aware motif scanning on pangenome graphs.

Publication: Journal Article

Tognon, Manuel, Vincenzo Bonnici, Erik Garrison, Rosalba Giugno, and Luca Pinello. 2021. “GRAFIMO: Variant and Haplotype Aware Motif Scanning on Pangenome Graphs.”. PLoS Computational Biology 17 (9): e1009444.

Screening thousands of transcribed coding and non-coding regions reveals sequence determinants of RNA polymerase II elongation potential.

Publication: Journal Article

Vlaming, Hanneke, Claudia A Mimoso, Andrew R Field, Benjamin J E Martin, and Karen Adelman. 2022. “Screening Thousands of Transcribed Coding and Non-Coding Regions Reveals Sequence Determinants of RNA Polymerase II Elongation Potential.”. Nature Structural & Molecular Biology 29 (6): 613-20.

Region Capture Micro-C reveals coalescence of enhancers and promoters into nested microcompartments.

Publication: Journal Article

Goel, Viraat Y, Miles K Huseyin, and Anders S Hansen. 2023. “Region Capture Micro-C Reveals Coalescence of Enhancers and Promoters into Nested Microcompartments.”. Nature Genetics 55 (6): 1048-56.

Transcriptome variation in human tissues revealed by long-read sequencing.

Publication: Journal Article

Glinos, Dafni A, Garrett Garborcauskas, Paul Hoffman, Nava Ehsan, Lihua Jiang, Alper Gokden, Xiaoguang Dai, et al. 2022. “Transcriptome Variation in Human Tissues Revealed by Long-Read Sequencing.”. Nature 608 (7922): 353-59.

Cell type-specific genetic regulation of gene expression across human tissues.

Publication: Journal Article

Kim-Hellmuth, Sarah, François Aguet, Meritxell Oliva, Manuel Muñoz-Aguirre, Silva Kasela, Valentin Wucher, Stephane E Castel, et al. 2020. “Cell Type-Specific Genetic Regulation of Gene Expression across Human Tissues.”. Science (New York, N.Y.) 369 (6509).

Integrative dissection of gene regulatory elements at base resolution.

Publication: Journal Article

Chen, Zeyu, Nauman Javed, Molly Moore, Jingyi Wu, Gary Sun, Michael Vinyard, Alejandro Collins, Luca Pinello, Fadi J Najm, and Bradley E Bernstein. 2023. “Integrative Dissection of Gene Regulatory Elements at Base Resolution.”. Cell Genomics 3 (6): 100318.

Modeling epigenetic lesions that cause gliomas.

Publication: Journal Article

Rahme, Gilbert J, Nauman M Javed, Kaitlyn L Puorro, Shouhui Xin, Volker Hovestadt, Sarah E Johnstone, and Bradley E Bernstein. 2023. “Modeling Epigenetic Lesions That Cause Gliomas.”. Cell.

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These pages document central GRO resources, and are constantly being updated. Please contact us if you can't find what you are looking for. Data GRO groups have contributed data to the following major resources: https://www.encodeproject.org/ https://igvf.org/ https://gtexportal.org/home/ https:/...

Mario L. Suvà, M.D., Ph.D.

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Associate Professor of Pathology, Massachusetts General Hospital Co-Leader, Neuro-Oncology Program, DF/HCC Co-Leader, Cancer Program, Harvard Stem Cell Institute