Wei-Chao Huang, Ph.D.
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436 results found
Functional inference of gene regulation using single-cell multi-omics.
Kartha, Vinay K, Fabiana M Duarte, Yan Hu, Sai Ma, Jennifer G Chew, Caleb A Lareau, Andrew Earl, et al. 2022. “Functional Inference of Gene Regulation Using Single-Cell Multi-Omics.”. Cell Genomics 2 (9).
Drug addiction unveils a repressive methylation ceiling in EZH2-mutant lymphoma.
Kwok, Hui Si, Allyson M Freedy, Allison P Siegenfeld, Julia W Morriss, Amanda L Waterbury, Stephen M Kissler, and Brian B Liau. 2023. “Drug Addiction Unveils a Repressive Methylation Ceiling in EZH2-Mutant Lymphoma.”. Nature Chemical Biology.
Epigenetic clocks, aging, and cancer.
Johnstone, Sarah E, Vadim N Gladyshev, Martin J Aryee, and Bradley E Bernstein. 2022. “Epigenetic Clocks, Aging, and Cancer.”. Science (New York, N.Y.) 378 (6626): 1276-77.
Spatial genomics enables multi-modal study of clonal heterogeneity in tissues.
Zhao, Tongtong, Zachary D Chiang, Julia W Morriss, Lindsay M LaFave, Evan M Murray, Isabella Del Priore, Kevin Meli, et al. 2022. “Spatial Genomics Enables Multi-Modal Study of Clonal Heterogeneity in Tissues.”. Nature 601 (7891): 85-91.
Dynamics of CTCF- and cohesin-mediated chromatin looping revealed by live-cell imaging.
Gabriele, Michele, Hugo B Brandão, Simon Grosse-Holz, Asmita Jha, Gina M Dailey, Claudia Cattoglio, Tsung-Han S Hsieh, Leonid Mirny, Christoph Zechner, and Anders S Hansen. 2022. “Dynamics of CTCF- and Cohesin-Mediated Chromatin Looping Revealed by Live-Cell Imaging.”. Science (New York, N.Y.) 376 (6592): 496-501.
LungMAP Portal Ecosystem: Systems-Level Exploration of the Lung.
Gaddis, Nathan, Joshua Fortriede, Minzhe Guo, Eric E Bardes, Michal Kouril, Scott Tabar, Kevin Burns, et al. 2022. “LungMAP Portal Ecosystem: Systems-Level Exploration of the Lung.”. American Journal of Respiratory Cell and Molecular Biology.
FDX1 regulates cellular protein lipoylation through direct binding to LIAS
Dreishpoon, Margaret B, Nolan R Bick, Boryana Petrova, Douglas M Warui, Alison Cameron, Squire J Booker, Naama Kanarek, Todd R Golub, and Peter Tsvetkov. 2023. “FDX1 Regulates Cellular Protein Lipoylation through Direct Binding to LIAS”. J Biol Chem 299 (9).
JUMP Cell Painting protocol (v3) in press
The newly optimized version 3 of the protocol has been accepted! It is in press at Nature Protocols as Cimini et al. 2023.
Two publicly available portals to explore the data
Ardigen’s phenAID portal The phenAID JUMP-CP Explorer was created by the Ardigen Data Science and Software Development team to enable easy access and visualization of JUMP-CP data. The web-based application shows a phenotypic and structural representation of the data set colored by clusters. Users...