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26 results found

Biological concepts in human sodium channel epilepsies and their relevance in clinical practice

Publication: Journal Article

Brunklaus, Andreas, Juanjiangmeng Du, Felix Steckler, Ismael Ghanty, Katrine Johannesen, Christina Dühring Fenger, Stephanie Schorge, et al. 2020. “Biological Concepts in Human Sodium Channel Epilepsies and Their Relevance in Clinical Practice”. Epilepsia 61 (3): 387–399.

Characterizing sleep spindles in 11,630 individuals from the National Sleep Research Resource

Publication: Journal Article

Purcell, SM, DS Manoach, Demanuele, BE Cade, Mariani, Cox, Panagiotaropoulou, et al. 2017. “Characterizing Sleep Spindles in 11,630 Individuals from the National Sleep Research Resource”. Nature Communications 8 (1): 1–16.

Reduced sleep spindles in schizophrenia: a treatable endophenotype that links risk genes to impaired cognition?

Publication: Journal Article

Manoach, Dara, Jen Pan, Shaun Purcell, and Robert Stickgold. 2016. “Reduced Sleep Spindles in Schizophrenia: A Treatable Endophenotype That Links Risk Genes to Impaired Cognition?”. Biological Psychiatry 80 (8): 599–608.

Micro-electrode array recordings reveal reductions in both excitation and inhibition in cultured cortical neuron networks lacking Shank3

Publication: Journal Article

Lu, Chen, Zhou, Bozic, Fu, JQ Pan, and Feng. 2016. “Micro-Electrode Array Recordings Reveal Reductions in Both Excitation and Inhibition in Cultured Cortical Neuron Networks Lacking Shank3”. Molecular Psychiatry 21 (2): 159–168.

Lingling Yang, Ph.D.

Person: Research Scientist II

Lingling Yang is a research scientist I at the Stanley Center for Psychiatric Research at the Broad Institute of MIT and Harvard, working under the direction of Jen Q. Pan. Yang uses biochemical and molecular biological imaging, as well as next-generation sequencing techniques, to interrogate the...

Nikita Budnik, B.S.

Person: Research Associate I

Nikita completed his Cognitive Science Bachelor's degree from McGill university in the spring of 2019 focusing in the fields of Neuroscience and Philosophy. In February of 2020 he joined the Stanley Centre of the Broad institute working in the "Brain Interaction Network" team under PIs Kaspar Lage...

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The Pan Lab has created PatchAnalytics, a cloud-based web application for automated analysis of SyncroPatch Data. PatchAnalytics Contributors: Lei A. Wang, Ziyue Zhu, David Zhou, David Baez, Yining Wang The Pan Lab has created IntelliSleepScorer, a software package with a graphic user interface for...

Selective inhibition of glycogen synthase kinase 3α corrects pathophysiology in a mouse model of fragile X syndrome

Publication: Journal Article

McCamphill, Patrick, Laura Stoppel, Rebecca Senter, Michael Lewis, Arnold Heynen, David Stoppel, Vinay Sridhar, et al. 2020. “Selective Inhibition of Glycogen Synthase Kinase 3α Corrects Pathophysiology in a Mouse Model of Fragile X Syndrome”. Science Translational Medicine 12 (544).

Exploiting an Asp-Glu “switch” in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia

Publication: Journal Article

Wagner, Florence, Lina Benajiba, Arthur Campbell, Michel We{\"ıwer, Joshua Sacher, Jennifer Gale, Linda Ross, et al. 2018. “Exploiting an Asp-Glu ‘switch’ in Glycogen Synthase Kinase 3 to Design Paralog-Selective Inhibitors for Use in Acute Myeloid Leukemia”. Science Translational Medicine 10 (431).

Overexpression of NEUROG2 and NEUROG1 in human embryonic stem cells produces a network of excitatory and inhibitory neurons

Publication: Journal Article

Lu, Congyi, Xi Shi, Andrew Allen, David Baez-Nieto, Alexandria Nikish, Neville Sanjana, and Jen Pan. 2019. “Overexpression of NEUROG2 and NEUROG1 in Human Embryonic Stem Cells Produces a Network of Excitatory and Inhibitory Neurons”. The FASEB Journal 33 (4): 5287–5299.