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Papers

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For our latest work, check out our preprints on bioRxiv! ( Carpenter) ( Singh) Google Scholar pages (with citation metrics): ( Carpenter) ( Singh) 215. Seal S, Dee W, Shah A, Cerisier N, Zhang A, Miglietta E, Titterton K, Cabrera AA, Boiko D, Beatson A, Slabaugh G, Taboureau O, Carreras Puigvert J...

Selective inhibition of glycogen synthase kinase 3α corrects pathophysiology in a mouse model of fragile X syndrome

Publication: Journal Article

McCamphill, Patrick, Laura Stoppel, Rebecca Senter, Michael Lewis, Arnold Heynen, David Stoppel, Vinay Sridhar, et al. 2020. “Selective Inhibition of Glycogen Synthase Kinase 3α Corrects Pathophysiology in a Mouse Model of Fragile X Syndrome”. Science Translational Medicine 12 (544).

Exploiting an Asp-Glu “switch” in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia

Publication: Journal Article

Wagner, Florence, Lina Benajiba, Arthur Campbell, Michel We{\"ıwer, Joshua Sacher, Jennifer Gale, Linda Ross, et al. 2018. “Exploiting an Asp-Glu ‘switch’ in Glycogen Synthase Kinase 3 to Design Paralog-Selective Inhibitors for Use in Acute Myeloid Leukemia”. Science Translational Medicine 10 (431).

Overexpression of NEUROG2 and NEUROG1 in human embryonic stem cells produces a network of excitatory and inhibitory neurons

Publication: Journal Article

Lu, Congyi, Xi Shi, Andrew Allen, David Baez-Nieto, Alexandria Nikish, Neville Sanjana, and Jen Pan. 2019. “Overexpression of NEUROG2 and NEUROG1 in Human Embryonic Stem Cells Produces a Network of Excitatory and Inhibitory Neurons”. The FASEB Journal 33 (4): 5287–5299.

Acoustic tweezers for the life sciences

Publication: Journal Article

Ozcelik, Adem, Joseph Rufo, Feng Guo, Yuyang Gu, Peng Li, James Lata, and Tony Jun Huang. 2018. “Acoustic Tweezers for the Life Sciences”. Nature Methods 15 (12): 1021–1028.

James Coleman, B.S.

Person: Research Associate I

Before graduating from Northeastern University in May 2020 with a BS in behavioral neuroscience, James was involved in research studying sleep, memory and pharmacology using both neuroimaging and electrophysiological approaches. His undergraduate thesis was on the neurological and behavioral effects...

Research

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KIDNEY DISEASE Autosomal dominant MUC1 kidney disease (MKD, also known as ADTKD-MUC1, and formerly called MCKD1) is a rare hereditary renal disease that ultimately requires dialysis or kidney transplantation for patients. For decades, scientists had known the genetic “neighborhood” of the mutation...

Effects of 3D culturing conditions on the transcriptomic profile of stem-cell-derived neurons

Publication: Journal Article

Tekin, Halil, Sean Simmons, Beryl Cummings, Linyi Gao, Xian Adiconis, Cynthia Hession, Ayan Ghoshal, et al. 2018. “Effects of 3D Culturing Conditions on the Transcriptomic Profile of Stem-Cell-Derived Neurons”. Nature Biomedical Engineering 2 (7): 540–554.

ANNA GREKA MD, PHD

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Anna Greka, M.D., Ph.D. Institute Member, Director of the Kidney Disease Initiative Anna Greka is an institute member of the Broad Institute of MIT and Harvard, where she leads a program focused on dissecting basic molecular and cellular mechanisms that may ultimately serve as the foundation for the...

Savannah (Savvy) Cornett, B.A.

Person: Research Associate I

Savannah (Savvy for short) received their bachelors of arts from Hampshire College in 2019. At Hampshire, they studied animal behavior and neuroendocrinology, and conducted their senior thesis project on peptide hormone function in the absence of a cognate receptor. They joined the Pan Lab group in...