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HiC-bench: Comprehensive and Reproducible Hi-C data Analysis Designed for Parameter Exploration and Benchmarking

Publication: Journal Article

Lazaris, Charalampos, Stephen Kelly, Panagiotis Ntziachristos, Iannis Aifantis, and Aristotelis Tsirigos. 2017. “HiC-Bench: Comprehensive and Reproducible Hi-C Data Analysis Designed for Parameter Exploration and Benchmarking”. BMC Genomics 18: 22-22.

Three-dimensional Chromatin Landscapes in T cell Acute Lymphoblastic Leukemia

Publication: Journal Article

Kloetgen, Andreas, Palaniraja Thandapani, Panagiotis Ntziachristos, Yohana Ghebrechristos, Sofia Nomikou, Charalampos Lazaris, Xufeng Chen, et al. 2020. “Three-Dimensional Chromatin Landscapes in T Cell Acute Lymphoblastic Leukemia”. Nat Genet 52: 388-400.

Cell Cycle Jurkat Cells

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Accession number BBBC048 · Version 1 Example images Biological application Abstract: We show that deep convolutional neural networks combined with nonlinear dimension reduction enable reconstructing biological processes based on raw image data. We demonstrate this by reconstructing the cell cycle of...

On Epigenetic Plasticity and Genome Topology

Publication: Journal Article

Lazaris, Charalampos, Iannis Aifantis, and Aristotelis Tsirigos. 2020. “On Epigenetic Plasticity and Genome Topology”. Trends Cancer 6: 177-80.

Role of Dysregulated Cytokine Signaling and Bacterial Triggers in the Pathogenesis of Cutaneous T-Cell Lymphoma

Publication: Journal Article

Fanok, Melania H., Amy Sun, Laura K. Fogli, Vijay Narendran, Miriam Eckstein, Kasthuri Kannan, Igor Dolgalev, et al. 2018. “Role of Dysregulated Cytokine Signaling and Bacterial Triggers in the Pathogenesis of Cutaneous T-Cell Lymphoma”. J Invest Dermatol 138: 1116-25.

FBXW7 Modulates Cellular Stress Response and Metastatic Potential Through HSF1 Post-translational Modification

Publication: Journal Article

Kourtis, Nikos, Rana S. Moubarak, Beatriz Aranda-Orgilles, Kevin Lui, Iraz T. Aydin, Thomas Trimarchi, Farbod Darvishian, et al. 2015. “FBXW7 Modulates Cellular Stress Response and Metastatic Potential Through HSF1 Post-Translational Modification”. Nat Cell Biol 17: 322-32.

Human U2OS cells – Small molecule Cell Painting experiment

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Accession number BBBC040 · Version 1 Example images Biological application An ideal small-molecule screening library would be enriched in non-redundant bioactive compounds that maximize the performance diversity of the library. The construction of such libraries would be aided by a rapid feedback...

2022 Dates Announced: From Images to Knowledge with ImageJ & Friends (I2K)

News: August 18, 2020

Originally slated for Fall of 2020, we are excited to announce new dates for the "From Images to Knowledge with ImageJ & Friends (I2K)" conference: Sept 23-24, 2021 May 9-10, 2022! Watch here for more info.

Dr. Richard A. Young

Person: Institute Member, Whitehead Institute for Biomedical Research, Professor of Biology, Massachusetts Institute of Technology

Nuclei of mouse embryonic cells

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Accession number BBBC050 · Version 2 Example images Biological application Cell dynamics during the early mouse embryogenesis change spatiotemporally. For understanding the mechanism of this developmental process, imaging cell dynamics by live-cell imaging of fluorescently labeled nuclei and...