Search

Search results

11 results found

Correction Synthetic Lethal Interaction between the ESCRTParalog Enzymes VPS4A and VPS4B in CancersHarboring Loss of Chromosome 18q or 16q

Publication: Report

Neggers, Jasper E., Brenton R. Paolella, Adhana Asfaw, Michael V. Rothberg, Thomas A. Skipper, Annan Yang, Radha L. Kalekar, et al. 2020. “Correction Synthetic Lethal Interaction Between the ESCRTParalog Enzymes VPS4A and VPS4B in CancersHarboring Loss of Chromosome 18q or 16q.”

New CellProfiler 4 Plugin: RunCellpose

Blog: August 26, 2021

David R. Stirling Hi everyone, Today we’re releasing the RunCellpose plugin for CellProfiler 4! This plugin is designed to allow you to use the popular Cellpose segmentation algorithm to generate object sets within a CellProfiler pipeline. Cellpose uses a neural network followed by post-processing...

FATTY ACID SYNTHESIS IS REQUIRED FOR BREAST CANCER BRAIN METASTASIS

Publication: Journal Article

Ferraro, Gino B, Ahmed Ali, Alba Luengo, David P Kodack, Amy Deik, Keene L Abbott, Divya Bezwada, et al. 2021. “FATTY ACID SYNTHESIS IS REQUIRED FOR BREAST CANCER BRAIN METASTASIS”. Nat Cancer 2 (4): 414-28.

Pluripotent stem cell-derived models of neurological diseases reveal early transcriptional heterogeneity

Publication: Journal Article

Sorek, Matan, Walaa Oweis, Malka Nissim-Rafinia, Moria Maman, Shahar Simon, Cynthia C. Hession, Xian Adiconis, et al. 2021. “Pluripotent Stem Cell-Derived Models of Neurological Diseases Reveal Early Transcriptional Heterogeneity”. Genome Biology .

Selective modulation of a pan-essential protein as a therapeutic strategy in cancer

Publication: Journal Article

Malone, Clare F., Neekesh V. Dharia, Guillaume Kugener, Alexandra B. Forman, Michael V. Rothberg, Mai Abdusamad, Alfredo Gonzalez, et al. 2021. “Selective Modulation of a Pan-Essential Protein As a Therapeutic Strategy in Cancer”. Cancer Discov.

Different roles of T-type calcium channel isoforms in hypnosis induced by an endogenous neurosteroid epipregnanolone

Publication: Journal Article

Coulter, Ian, Tamara Timic Stamenic, Pierce Eggan, Brier R Fine, Timothy Corrigan, Douglas F Covey, Lingling Yang, Jen Q Pan, and Slobodan M Todorovic. 2021. “Different Roles of T-Type Calcium Channel Isoforms in Hypnosis Induced by an Endogenous Neurosteroid Epipregnanolone”. Neuropharmacology.

Help! How does the Robust Background method work?

Blog: August 05, 2021

Pearl V. Ryder The Robust Background algorithm is a powerful algorithm for automatically setting thresholds to segment objects of interest when your image contains mostly background. However, since it contains the largest number of tunable parameters of any thresholding algorithm in CellProfiler, it...

Thinking like an image analyst, Part II: Removing bright debris from analysis

Blog: August 17, 2021

Pearl V. Ryder In the first post of this series, I gave an overview of this project and explained how I imported the data into CellProfiler. If you’d like to follow along in CellProfiler, the pipeline and images for this project are available here. Now that the images have been imported, I could...

Daya Mena, B.A.

Person: Research Associate I

Daya Mena completed her BA in Biomedical Sciences at Hampshire College in 2019, while concentrating on Biomedical and Biomathematical Sciences. Her undergraduate thesis was on using mathematical modeling to predict the impact of gene editing on HIV therapy. Alongside her studies, Daya served on the...

David Baez-Nieto, Ph.D.

Person: Senior Scientist I

David Baez-Nieto, Ph.D., is a Senior Research Scientist specializing in ion channel pharmacology and drug discovery for neuropsychiatric and neurodegenerative disorders. He earned his Ph.D. in Neuroscience from the Universidad de Valparaíso, Chile, and has worked in both academia and industry...