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Phosphate dysregulation via the XPR1-KIDINS220 protein complex is a therapeutic vulnerability in ovarian cancer

Publication: Journal Article

Bondeson, Daniel P, Brenton R Paolella, Adhana Asfaw, Michael V. Rothberg, Thomas A Skipper, Carly Langan, Gabriel Mesa, et al. 2022. “Phosphate Dysregulation via the XPR1-KIDINS220 Protein Complex Is a Therapeutic Vulnerability in Ovarian Cancer”. Nat Cancer 3 (6): 681-95.

Ned Martenis

Person: Research Associate III

William “Ned” Martenis is a therapeutics group research associate affiliated with the Pan and Sheng labs, where he primarily develops, troubleshoots, and runs high-throughput assays designed to better understand psychiatric disease. Most prominently, Ned is working on a drug discovery project that...

Raozhou Lin, Ph.D.

Person: Research Scientist II

Raozhou Lin is a molecular neuroscientist with a keen interest in understanding the causes for neuropsychiatric diseases. He was first trained as a molecular biologist in the University of Hong Kong, where he obtained his PhD. Then he joined Dr. Paul Worley’s lab in the Johns Hopkins University for...

Nathaniel Goble

Person: Research Associate II

Nathaniel Goble graduated from the University of Southern California in 2021 with a major in neuroscience and minor in philosophy. Nathaniel earned his MA in psychology from Boston University in 2022 where he researched drug addiction in animal models. HIs specialties include small animal surgery...

Massively parallel enrichment of low-frequency alleles enables duplex sequencing at low depth

Publication: Journal Article

Gydush, Gregory, Erica Nguyen, Jin H Bae, Timothy Blewett, Justin Rhoades, Sarah C Reed, Douglas Shea, et al. 2022. “Massively Parallel Enrichment of Low-Frequency Alleles Enables Duplex Sequencing at Low Depth”. Nat Biomed Eng 6 (3): 257-66.

Publisher Correction: DNA-based copy number analysisconfirms genomic evolution of PDX models.

Publication: Journal Article

Hoge, Anna C H, Michal Getz, Anat Zimmer, Minjeong Ko, Linoy Raz, Rameen Beroukhim, Todd R. Golub, Gavin Ha, and Uri Ben-David. 2022. “Publisher Correction: DNA-Based Copy Number Analysisconfirms Genomic Evolution of PDX Models.”. NPJ Precis Oncol 6 (50).

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We seek to understand the genetic basis of common diseases and to translate genetic association data into biological insights. Most of our research involves the development of new statistical methods and the application of these methods to large-scale genetic datasets. Genetic architecture of common...

DNA-based copy number analysis confirms genomic evolution of PDX models

Publication: Journal Article

Hoge, Anna C H, , Anat Zimmer, Minjeong Ko, Linoy Raz, Rameen Beroukhim, Todd R Golub, Gavin Ha, and Uri Ben David. 2022. “DNA-Based Copy Number Analysis Confirms Genomic Evolution of PDX Models”. NPJ Precis Oncol 6 (1): 30.

UnmixColors Modules Tutorial

Blog: July 22, 2022

Mario Costa Cruz If you have color images stained with light-absorbing dyes, the UnmixColors module might be able to separate the dyes into separate channels so that they can be analyzed separately. Separating the dyes into channels can be a difficult task with traditional methods such as split...

Copper induces cell death by targeting lipoylated TCA cycle proteins

Publication: Journal Article

Tsvetkov, Peter, Shannon Coy, Boryana Petrova, Margaret Dreishpoon, Ana Verma, Mai Abdusamad, Jordan Rossen, et al. 2022. “Copper Induces Cell Death by Targeting Lipoylated TCA Cycle Proteins”. Science 375 (6586): 1254-61.