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Jason Buenrostro named a 2023 MacArthur Fellow

News: October 04, 2023

Our GRO Co-Director Jason Buenrostro is named in the 2023 cohort of MacArthur Genius Grant Fellows, in recognition of his impact in tool and technology development thus far, and for his ongoing research in gene regulation and cellular function. Check out his MacArthur Foundation bio here, and an...

An autoinhibitory switch of the LSD1 disordered region controls enhancer silencing.

Publication: Journal Article

Waterbury, Amanda L, Hui Si Kwok, Ceejay Lee, Domenic N Narducci, Allyson M Freedy, Cindy Su, Shaunak Raval, et al. 2024. “An Autoinhibitory Switch of the LSD1 Disordered Region Controls Enhancer Silencing.”. Molecular Cell 84 (12): 2238-2254.e11.

Dissection of a CTCF topological boundary uncovers principles of enhancer-oncogene regulation.

Publication: Journal Article

Kim, Kyung Lock, Gilbert J Rahme, Viraat Y Goel, Chadi A El Farran, Anders S Hansen, and Bradley E Bernstein. 2024. “Dissection of a CTCF Topological Boundary Uncovers Principles of Enhancer-Oncogene Regulation.”. Molecular Cell 84 (7): 1365-1376.e7.

Functional inference of gene regulation using single-cell multi-omics.

Publication: Journal Article

Kartha, Vinay K, Fabiana M Duarte, Yan Hu, Sai Ma, Jennifer G Chew, Caleb A Lareau, Andrew Earl, et al. 2022. “Functional Inference of Gene Regulation Using Single-Cell Multi-Omics.”. Cell Genomics 2 (9).

Drug addiction unveils a repressive methylation ceiling in EZH2-mutant lymphoma.

Publication: Journal Article

Kwok, Hui Si, Allyson M Freedy, Allison P Siegenfeld, Julia W Morriss, Amanda L Waterbury, Stephen M Kissler, and Brian B Liau. 2023. “Drug Addiction Unveils a Repressive Methylation Ceiling in EZH2-Mutant Lymphoma.”. Nature Chemical Biology.

Epigenetic clocks, aging, and cancer.

Publication: Journal Article

Johnstone, Sarah E, Vadim N Gladyshev, Martin J Aryee, and Bradley E Bernstein. 2022. “Epigenetic Clocks, Aging, and Cancer.”. Science (New York, N.Y.) 378 (6626): 1276-77.

Spatial genomics enables multi-modal study of clonal heterogeneity in tissues.

Publication: Journal Article

Zhao, Tongtong, Zachary D Chiang, Julia W Morriss, Lindsay M LaFave, Evan M Murray, Isabella Del Priore, Kevin Meli, et al. 2022. “Spatial Genomics Enables Multi-Modal Study of Clonal Heterogeneity in Tissues.”. Nature 601 (7891): 85-91.

Dynamics of CTCF- and cohesin-mediated chromatin looping revealed by live-cell imaging.

Publication: Journal Article

Gabriele, Michele, Hugo B Brandão, Simon Grosse-Holz, Asmita Jha, Gina M Dailey, Claudia Cattoglio, Tsung-Han S Hsieh, Leonid Mirny, Christoph Zechner, and Anders S Hansen. 2022. “Dynamics of CTCF- and Cohesin-Mediated Chromatin Looping Revealed by Live-Cell Imaging.”. Science (New York, N.Y.) 376 (6592): 496-501.

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Blog: April 18, 2023

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Blog: April 18, 2023

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