The Somatic Mosaicism across Human Tissues (SMaHT) Network aims to transform our understanding of how somatic mosaicism in human cells influences biology and disease. GRO members Kristin Ardlie, Jason Buenrostro, Fei Chen, and Bradley Bernstein (and their collaborators) were all awarded grants in this new common fund program.
Key outcomes of the SMaHT Network include:
• A catalog of somatic variants in select tissues from diverse human donors
• Innovative sequencing tools and analysis methods that optimize variant detection
• A SMaHT data workbench that seamlessly integrates with current tools to study DNA sequences, like genome browsers, and combines analysis of somatic variation with the current human genome
• Fundamentally new ways of understanding the contribution of somatic variation to human biology through the development of new technologies, analysis methods, and extensive datasets
https://commonfund.nih.gov/smaht