The audacious goal of the GRO is to build an atlas of the function of every base in the non-coding genome. We believe that achieving this goal will accelerate all aspects of genomic medicine by underpinning efforts to: understand the function of disease-associated variants, generate new targetable pathways & mechanisms, and design new cellular therapies.
GRO labs contribute to the NHGRI Impact of Genomic Variation on Function consortium. The IGVF consortium aims to understand how genomic variation affects genome function, which in turn impacts phenotype. We have also contributed thousands of datasets to the ENCODE Encyclopedia of regulatory elements.
Kristin Ardlie leads the GTEx, developmental GTEx, and non-human primate GTEx projects. The continuing goal of the GTEx projects is to established a data resource and tissue bank to study the relationship between genetic variants and gene expression in multiple human tissues and across individuals.
We work closely with the Novo Nordisk Foundation Center for Genomic Mechanisms of Disease to create a human gene regulation map in cell types of relevance for metabolic disease.
Our Team
The GRO brings together a dedicated team of scientists across multiple programs and partner institutions to collaborate on flagship projects, focused on investigating the functions of elements and genetic variants in specific biological contexts and diseases.
Meet our Investigators
Meet our Leadership
Meet our team of Staff Members based at the Broad Institute