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Autophagy regulates tumor growth and metastasis.

Publication: Journal Article

Qiang, Lei, Baozhong Zhao, Mei Ming, Ning Wang, Tong-Chuan He, Seungmin Hwang, Andrew Thorburn, and Yu-Ying He. 2023. “Autophagy Regulates Tumor Growth and Metastasis.”. BioRxiv.

Seungmin "Sam" Hwang

Person: Principal Investigator

Seungmin “Sam” Hwang is a senior translation group leader within the Center for Integrated Solutions for Infectious Diseases ( CISID) at the Broad Institute of MIT and Harvard. Hwang joined the Broad Institute in September 2023, and the focus of his research is to elucidate the mechanisms of organ...

Publications

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https://www.ncbi.nlm.nih.gov/myncbi/seungmin.hwang.1/bibliography/public/ 1. Park J, Seo T, Hwang S, Lee D, Gwack Y, Choe J. 2000. The K-bZIP protein from Kaposi's sarcoma-associated herpesvirus interacts with p53 and represses its transcriptional activity. J Virol 74:11977-82. 2. Lim C, Gwack Y...

Chukwudumebi Okonkwo

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CD300LF Polymorphisms of Inbred Mouse Strains Confer Resistance to Murine Norovirus Infection in a Cell Type-Dependent Manner.

Publication: Journal Article

Furlong, Kevin, Scott B Biering, Jayoung Choi, Craig B Wilen, Robert C Orchard, Christiane E Wobus, Christopher A Nelson, et al. 2020. “CD300LF Polymorphisms of Inbred Mouse Strains Confer Resistance to Murine Norovirus Infection in a Cell Type-Dependent Manner.”. Journal of Virology 94 (17).

Murine Norovirus Infection Induces TH1 Inflammatory Responses to Dietary Antigens.

Publication: Journal Article

Bouziat, Romain, Scott B Biering, Elaine Kouame, Kishan A Sangani, Soowon Kang, Jordan D Ernest, Mukund Varma, et al. 2018. “Murine Norovirus Infection Induces TH1 Inflammatory Responses to Dietary Antigens.”. Cell Host & Microbe 24 (5): 677-688.e5.

LysMD3 is a type II membrane protein without an in vivo role in the response to a range of pathogens.

Publication: Journal Article

Yokoyama, Christine C, Megan T Baldridge, Daisy W Leung, Guoyan Zhao, Chandni Desai, Ta-Chiang Liu, Vladimir E Diaz-Ochoa, et al. 2018. “LysMD3 Is a Type II Membrane Protein Without an in Vivo Role in the Response to a Range of Pathogens.”. The Journal of Biological Chemistry 293 (16): 6022-38.

Quo vadis? Interferon-inducible GTPases go to their target membranes via the LC3-conjugation system of autophagy.

Publication: Journal Article

Choi, Jayoung, Scott B Biering, and Seungmin Hwang. 2017. “Quo Vadis? Interferon-Inducible GTPases Go to Their Target Membranes via the LC3-Conjugation System of Autophagy.”. Small GTPases 8 (4): 199-207.

Targeting by AutophaGy proteins (TAG): Targeting of IFNG-inducible GTPases to membranes by the LC3 conjugation system of autophagy.

Publication: Journal Article

Park, Sungwoo, Jayoung Choi, Scott B Biering, Erin Dominici, Lelia E Williams, and Seungmin Hwang. 2016. “Targeting by AutophaGy Proteins (TAG): Targeting of IFNG-Inducible GTPases to Membranes by the LC3 Conjugation System of Autophagy.”. Autophagy 12 (7): 1153-67.

Gamma-herpesvirus kinase actively initiates a DNA damage response by inducing phosphorylation of H2AX to foster viral replication.

Publication: Journal Article

Tarakanova, Vera L, Van Leung-Pineda, Seungmin Hwang, Chiao-Wen Yang, Katie Matatall, Mickael Basson, Ren Sun, Helen Piwnica-Worms, Barry P Sleckman, and Herbert W Virgin. 2007. “Gamma-Herpesvirus Kinase Actively Initiates a DNA Damage Response by Inducing Phosphorylation of H2AX to Foster Viral Replication.”. Cell Host & Microbe 1 (4): 275-86.