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Drug addiction unveils a repressive methylation ceiling in EZH2-mutant lymphoma.

Publication: Journal Article

Kwok, Hui Si, Allyson M Freedy, Allison P Siegenfeld, Julia W Morriss, Amanda L Waterbury, Stephen M Kissler, and Brian B Liau. 2023. “Drug Addiction Unveils a Repressive Methylation Ceiling in EZH2-Mutant Lymphoma.”. Nature Chemical Biology.

Epigenetic clocks, aging, and cancer.

Publication: Journal Article

Johnstone, Sarah E, Vadim N Gladyshev, Martin J Aryee, and Bradley E Bernstein. 2022. “Epigenetic Clocks, Aging, and Cancer.”. Science (New York, N.Y.) 378 (6626): 1276-77.

Spatial genomics enables multi-modal study of clonal heterogeneity in tissues.

Publication: Journal Article

Zhao, Tongtong, Zachary D Chiang, Julia W Morriss, Lindsay M LaFave, Evan M Murray, Isabella Del Priore, Kevin Meli, et al. 2022. “Spatial Genomics Enables Multi-Modal Study of Clonal Heterogeneity in Tissues.”. Nature 601 (7891): 85-91.

Dynamics of CTCF- and cohesin-mediated chromatin looping revealed by live-cell imaging.

Publication: Journal Article

Gabriele, Michele, Hugo B Brandão, Simon Grosse-Holz, Asmita Jha, Gina M Dailey, Claudia Cattoglio, Tsung-Han S Hsieh, Leonid Mirny, Christoph Zechner, and Anders S Hansen. 2022. “Dynamics of CTCF- and Cohesin-Mediated Chromatin Looping Revealed by Live-Cell Imaging.”. Science (New York, N.Y.) 376 (6592): 496-501.

LungMAP Portal Ecosystem: Systems-Level Exploration of the Lung.

Publication: Journal Article

Gaddis, Nathan, Joshua Fortriede, Minzhe Guo, Eric E Bardes, Michal Kouril, Scott Tabar, Kevin Burns, et al. 2022. “LungMAP Portal Ecosystem: Systems-Level Exploration of the Lung.”. American Journal of Respiratory Cell and Molecular Biology.

FDX1 regulates cellular protein lipoylation through direct binding to LIAS

Publication: Journal Article

Dreishpoon, Margaret B, Nolan R Bick, Boryana Petrova, Douglas M Warui, Alison Cameron, Squire J Booker, Naama Kanarek, Todd R Golub, and Peter Tsvetkov. 2023. “FDX1 Regulates Cellular Protein Lipoylation through Direct Binding to LIAS”. J Biol Chem 299 (9).

JUMP Cell Painting protocol (v3) in press

News: December 01, 2022

The newly optimized version 3 of the protocol has been accepted! It is in press at Nature Protocols as Cimini et al. 2023.

Two publicly available portals to explore the data

News: March 28, 2023

Ardigen’s phenAID portal The phenAID JUMP-CP Explorer was created by the Ardigen Data Science and Software Development team to enable easy access and visualization of JUMP-CP data. The web-based application shows a phenotypic and structural representation of the data set colored by clusters. Users...

Data release & Manuscript in BioRxiv

News: March 28, 2023

We are excited to share that the JUMP Cell Painting Datasets now include most data components from all but one of the sources for the principal dataset (cpg0016), covering 116,000 chemical and over 20,000 genetic perturbations (covering ~15,000 genes). The first draft of metadata files are available...

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Blog: April 18, 2023

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