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Functional and dysfunctional T regulatory cell states in human tissues in RA and other autoimmune arthritic diseases.
Koh, Byunghee, Shani T Gal Oz, Ryota Sato, Hung N Nguyen, Garrett Dunlap, Chrisopher Mahony, Chrissy Bolton, et al. 2025. “Functional and Dysfunctional T Regulatory Cell States in Human Tissues in RA and Other Autoimmune Arthritic Diseases.”. BioRxiv : The Preprint Server for Biology.
Carl June, Bruce Levine, Isabelle Rivière, and Michel Sadelain receive the 2025 Merkin Prize at the Broad Institute for chimeric antigen receptor (CAR) T-cell therapy
This groundbreaking form of personalized cancer immunotherapy has had remarkable success — more than 45,000 cancer patients worldwide have been treated with CAR T-cell therapy, extending their lives and, in many cases, delivering complete and sustained remissions.
Modeling heterogeneity in single-cell perturbation states enhances detection of response eQTLs.
Valencia, Cristian, Aparna Nathan, Joyce B Kang, Laurie Rumker, Hyunsun Lee, and Soumya Raychaudhuri. 2025. “Modeling Heterogeneity in Single-Cell Perturbation States Enhances Detection of Response EQTLs.”. Nature Genetics.
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