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BRAF mutation predicts sensitivity to MEK inhibition
Solit D, Garraway L, Pratilas C, Sawai A, Getz G, Basso A, Ye Q, Lobo J, She Y, Osman I, et al. BRAF mutation predicts sensitivity to MEK inhibition. Nature. 2006;439(7074):358–62.
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Datasets
Processed Data CCLE data Broad DepMap Portal : The most recently processed and up-to-date CCLE datasets along with many perturbation datasets. List of Cell lines Cell line annotations Genetic Data Merged mutation calls (Coding regions, germlin filtered) CCLE structural variants (SvABA calls) for 329...
Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia
Jaffe J, Wang Y, Chan HM, Zhang J, Huether R, Kryukov G, Bhang H- eun, Taylor J, Hu M, Englund N, et al. Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia. Nat Genet. 2013;45(11):1386–91.
Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma
Garraway L, Widlund H, Rubin M, Getz G, Berger A, Ramaswamy S, Beroukhim R, Milner D, Granter S, Du J, et al. Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma. Nature. 2005;436(7047):117–22.
News & Events
Next-generation characterization of the Cancer Cell Line Encyclopedia
Ghandi M, Huang F, Jané-Valbuena J, Kryukov G, Lo C, McDonald R, Barretina J, Gelfand E, Bielski C, Li H, et al. Next-generation characterization of the Cancer Cell Line Encyclopedia. Nature. 2019;569(7757):503–508.
Pharmacogenomic agreement between two cancer cell line data sets
Cancer Cell Line Encyclopedia Consortium, Genomics of Drug Sensitivity in Cancer Consortium. Pharmacogenomic agreement between two cancer cell line data sets. Nature. 2015;528(7580):84–7.