OpenScholar

Search results

24 results found

Extent and Context Dependence of Pleiotropy Revealed by High-throughput Single-cell Phenotyping

Publication: Journal Article

Geiler-Samerotte, Kerry A., Shuang Li, Charalampos Lazaris, Austin Taylor, Naomi Ziv, Chelsea Ramjeawan, Annalise B. Paaby, and Mark L. Siegal. 2020. “Extent and Context Dependence of Pleiotropy Revealed by High-Throughput Single-Cell Phenotyping”. PLoS Biol 18: e3000836-e3000836.

Opposing Functions of H2BK120 Ubiquitylation and H3K79 Methylation in the Regulation of Pluripotency by the Paf1 Complex

Publication: Journal Article

Strikoudis, Alexandros, Charalampos Lazaris, Panagiotis Ntziachristos, Aristotelis Tsirigos, and Iannis Aifantis. 2017. “Opposing Functions of H2BK120 Ubiquitylation and H3K79 Methylation in the Regulation of Pluripotency by the Paf1 Complex”. Cell Cycle 16: 2315-22.

The Ubiquitin Ligase Huwe1 Regulates the Maintenance and Lymphoid Commitment of Hematopoietic Stem Cells

Publication: Journal Article

King, Bryan, Francesco Boccalatte, Kelly Moran-Crusio, Elmar Wolf, Jingjing Wang, Clarisse Kayembe, Charalampos Lazaris, et al. 2016. “The Ubiquitin Ligase Huwe1 Regulates the Maintenance and Lymphoid Commitment of Hematopoietic Stem Cells”. Nat Immunol 17: 1312-21.

Human kidney cortex cells

Page

Accession number BBBC051 · Version 1 Example images Biological application The dataset was designed to train a classification algorithm to correctly identify cell types in the human kidney cortex. Images Confocal single channel images of DAPI fluorescence cropped from tissue sections. Images...

Three-dimensional Chromatin Landscapes in T cell Acute Lymphoblastic Leukemia

Publication: Journal Article

Kloetgen, Andreas, Palaniraja Thandapani, Panagiotis Ntziachristos, Yohana Ghebrechristos, Sofia Nomikou, Charalampos Lazaris, Xufeng Chen, et al. 2020. “Three-Dimensional Chromatin Landscapes in T Cell Acute Lymphoblastic Leukemia”. Nat Genet 52: 388-400.

Cell Cycle Jurkat Cells

Page

Accession number BBBC048 · Version 1 Example images Biological application Abstract: We show that deep convolutional neural networks combined with nonlinear dimension reduction enable reconstructing biological processes based on raw image data. We demonstrate this by reconstructing the cell cycle of...

Oncogenic Hijacking of the Stress Response Machinery in T cell Acute Lymphoblastic Leukemia

Publication: Journal Article

Kourtis, Nikos, Charalampos Lazaris, Kathryn Hockemeyer, Juan Carlos Balandrán, Alejandra R. Jimenez, Jasper Mullenders, Yixiao Gong, et al. 2018. “Oncogenic Hijacking of the Stress Response Machinery in T Cell Acute Lymphoblastic Leukemia”. Nat Med 24: 1157-66.

Stratification of TAD Boundaries Reveals Preferential Insulation of Super-enhancers by Strong Boundaries

Publication: Journal Article

Gong, Yixiao, Charalampos Lazaris, Theodore Sakellaropoulos, Aurelie Lozano, Prabhanjan Kambadur, Panagiotis Ntziachristos, Iannis Aifantis, and Aristotelis Tsirigos. 2018. “Stratification of TAD Boundaries Reveals Preferential Insulation of Super-Enhancers by Strong Boundaries”. Nat Commun 9: 542-42.

Low-Grade Astrocytoma Mutations in IDH1, P53, and ATRX Cooperate to Block Differentiation of Human Neural Stem Cells via Repression of SOX2

Publication: Journal Article

Modrek, Aram S., Danielle Golub, Themasap Khan, Devin Bready, Jod Prado, Christopher Bowman, Jingjing Deng, et al. 2017. “Low-Grade Astrocytoma Mutations in IDH1, P53, and ATRX Cooperate to Block Differentiation of Human Neural Stem Cells via Repression of SOX2”. Cell Rep 21: 1267-80.

Regulation of Transcriptional Elongation in Pluripotency and cell Differentiation by the PHD-finger Protein Phf5a

Publication: Journal Article

Strikoudis, Alexandros, Charalampos Lazaris, Thomas Trimarchi, Antonio L. Galvao Neto, Yan Yang, Panagiotis Ntziachristos, Scott Rothbart, et al. 2016. “Regulation of Transcriptional Elongation in Pluripotency and Cell Differentiation by the PHD-Finger Protein Phf5a”. Nat Cell Biol 18: 1127-38.