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HiC-bench: Comprehensive and Reproducible Hi-C data Analysis Designed for Parameter Exploration and Benchmarking

Publication: Journal Article

Lazaris, Charalampos, Stephen Kelly, Panagiotis Ntziachristos, Iannis Aifantis, and Aristotelis Tsirigos. 2017. “HiC-Bench: Comprehensive and Reproducible Hi-C Data Analysis Designed for Parameter Exploration and Benchmarking”. BMC Genomics 18: 22-22.

Extent and Context Dependence of Pleiotropy Revealed by High-throughput Single-cell Phenotyping

Publication: Journal Article

Geiler-Samerotte, Kerry A., Shuang Li, Charalampos Lazaris, Austin Taylor, Naomi Ziv, Chelsea Ramjeawan, Annalise B. Paaby, and Mark L. Siegal. 2020. “Extent and Context Dependence of Pleiotropy Revealed by High-Throughput Single-Cell Phenotyping”. PLoS Biol 18: e3000836-e3000836.

Opposing Functions of H2BK120 Ubiquitylation and H3K79 Methylation in the Regulation of Pluripotency by the Paf1 Complex

Publication: Journal Article

Strikoudis, Alexandros, Charalampos Lazaris, Panagiotis Ntziachristos, Aristotelis Tsirigos, and Iannis Aifantis. 2017. “Opposing Functions of H2BK120 Ubiquitylation and H3K79 Methylation in the Regulation of Pluripotency by the Paf1 Complex”. Cell Cycle 16: 2315-22.

The Ubiquitin Ligase Huwe1 Regulates the Maintenance and Lymphoid Commitment of Hematopoietic Stem Cells

Publication: Journal Article

King, Bryan, Francesco Boccalatte, Kelly Moran-Crusio, Elmar Wolf, Jingjing Wang, Clarisse Kayembe, Charalampos Lazaris, et al. 2016. “The Ubiquitin Ligase Huwe1 Regulates the Maintenance and Lymphoid Commitment of Hematopoietic Stem Cells”. Nat Immunol 17: 1312-21.

Human kidney cortex cells

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Accession number BBBC051 · Version 1 Example images Biological application The dataset was designed to train a classification algorithm to correctly identify cell types in the human kidney cortex. Images Confocal single channel images of DAPI fluorescence cropped from tissue sections. Images...

On Epigenetic Plasticity and Genome Topology

Publication: Journal Article

Lazaris, Charalampos, Iannis Aifantis, and Aristotelis Tsirigos. 2020. “On Epigenetic Plasticity and Genome Topology”. Trends Cancer 6: 177-80.

Role of Dysregulated Cytokine Signaling and Bacterial Triggers in the Pathogenesis of Cutaneous T-Cell Lymphoma

Publication: Journal Article

Fanok, Melania H., Amy Sun, Laura K. Fogli, Vijay Narendran, Miriam Eckstein, Kasthuri Kannan, Igor Dolgalev, et al. 2018. “Role of Dysregulated Cytokine Signaling and Bacterial Triggers in the Pathogenesis of Cutaneous T-Cell Lymphoma”. J Invest Dermatol 138: 1116-25.

FBXW7 Modulates Cellular Stress Response and Metastatic Potential Through HSF1 Post-translational Modification

Publication: Journal Article

Kourtis, Nikos, Rana S. Moubarak, Beatriz Aranda-Orgilles, Kevin Lui, Iraz T. Aydin, Thomas Trimarchi, Farbod Darvishian, et al. 2015. “FBXW7 Modulates Cellular Stress Response and Metastatic Potential Through HSF1 Post-Translational Modification”. Nat Cell Biol 17: 322-32.

Human U2OS cells – Small molecule Cell Painting experiment

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Accession number BBBC040 · Version 1 Example images Biological application An ideal small-molecule screening library would be enriched in non-redundant bioactive compounds that maximize the performance diversity of the library. The construction of such libraries would be aided by a rapid feedback...

2022 Dates Announced: From Images to Knowledge with ImageJ & Friends (I2K)

News: August 18, 2020

Originally slated for Fall of 2020, we are excited to announce new dates for the "From Images to Knowledge with ImageJ & Friends (I2K)" conference: Sept 23-24, 2021 May 9-10, 2022! Watch here for more info.